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      Cannabis and Driving

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          Abstract

          As more states in the U.S legalize recreational and medicinal cannabis, rates of driving under the influence of this drug are increasing significantly. Aspects of this emerging public health issue potentially pit science against public policy. The authors believe that the legal cart is currently significantly ahead of the scientific horse. Issues such as detection procedures for cannabis-impaired drivers, and use of blood THC levels to gauge impairment, should rely heavily on current scientific knowledge. However, there are many, often unacknowledged research gaps in these and related areas, that need to be addressed in order provide a more coherent basis for public policies. This review focuses especially on those areas. In this article we review in a focused manner, current information linking cannabis to motor vehicle accidents and examine patterns of cannabis-impairment of driving related behaviors, their time courses, relationship to cannabis dose and THC blood levels, and compare cannabis and alcohol-impaired driving patterns directly. This review also delves into questions of alcohol-cannabis combinations and addresses the basis for of per-se limits in cannabis driving convictions. Finally, we distinguish between areas where research has provided clear answers to the above questions, areas that remain unclear, and make recommendations to fill gaps in current knowledge.

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          Most cited references139

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          Human cannabinoid pharmacokinetics.

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            Pharmacology and effects of cannabis: a brief review.

            Increasing prevalence of recreational cannabis use among the young population has stimulated debate on the possible effects of acute and longterm use. To highlight recent knowledge of mechanisms of action, effects on psychomotor and cognitive performance, and health risks associated with cannabis consumption. A brief review of recent literature on the prevalence of recreational cannabis use, the potency of modern cannabis preparations and the pharmacological actions of cannabis. Cannabinoids derived from herbal cannabis interact with endogenous cannabinoid systems in the body. Actions on specific brain receptors cause dose-related impairments of psychomotor performance with implications for car and train driving, aeroplane piloting and academic performance. Other constituents of cannabis smoke carry respiratory and cardiovascular health risks similar to those of tobacco smoke. Cannabis is not, as widely perceived, a harmless drug but poses risks to the individual and to society.
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              The effects of cannabis intoxication on motor vehicle collision revisited and revised.

              To determine whether and to what extent acute cannabis intoxication increases motor vehicle crash risk.
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                Author and article information

                Contributors
                Journal
                Front Psychiatry
                Front Psychiatry
                Front. Psychiatry
                Frontiers in Psychiatry
                Frontiers Media S.A.
                1664-0640
                24 September 2021
                2021
                : 12
                : 689444
                Affiliations
                [1] 1Department of Psychiatry, Olin Neuropsychiatry Research Center, Institute of Living, Hartford Healthcare Corporation , Hartford, CT, United States
                [2] 2Department of Psychiatry, Yale University School of Medicine , New Haven, CT, United States
                [3] 3Department of Neuroscience, Yale University School of Medicine , New Haven, CT, United States
                Author notes

                Edited by: Amine Benyamina, Assistance Publique Hopitaux de Paris, France

                Reviewed by: Hollis C. Karoly, Colorado State University, United States; Bernard Le Foll, Centre for Addiction and Mental Health (CAMH), Canada; Justin Matheson, Centre for Addiction and Mental Health (CAMH), Canada, in Collaboration With Reviewer BLF

                *Correspondence: Godfrey D. Pearlson godfrey.pearlson@ 123456yale.edu

                This article was submitted to Addictive Disorders, a section of the journal Frontiers in Psychiatry

                Article
                10.3389/fpsyt.2021.689444
                8499672
                34630173
                1630b68f-5f2d-479a-8b34-b628ed2a00ba
                Copyright © 2021 Pearlson, Stevens and D'Souza.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 31 March 2021
                : 24 August 2021
                Page count
                Figures: 0, Tables: 4, Equations: 0, References: 149, Pages: 17, Words: 15232
                Funding
                Funded by: National Highway Traffic Safety Administration, doi 10.13039/100008760;
                Funded by: National Institute on Drug Abuse, doi 10.13039/100000026;
                Categories
                Psychiatry
                Review

                Clinical Psychology & Psychiatry
                cannabis use,driving impairment,motor vehicle driving,public health,roadside testing,thc,cannabinoids

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