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Abstract

Corazonin, a new cardioaccelerating peptide, has been isolated from the corpora cardiaca of the American cockroach, Periplaneta americana, and its structure determined to be Glp-Thr-Phe-Gln-Tyr-Ser-Arg-Gly-Trp-Thr-Asn-amide. The peptide stimulated heart beat at concentrations as low as 0.2 nM, which makes it the most potent insect cardioactive neuropeptide.

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PubMed ID:: 2753132

DOI:: 10.1016/0014-5793(89)80727-6

ScienceOpen disciplines: Chemistry

Keywords: Animals,Chromatography, High Pressure Liquid,Cockroaches,Heart,drug effects,Insect Proteins,Molecular Conformation,Neuropeptides,isolation & purification,pharmacology,Peptides

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ScienceOpen disciplines: Chemistry

Keywords: Animals, Chromatography, High Pressure Liquid, Cockroaches, Heart, drug effects, Insect Proteins, Molecular Conformation, Neuropeptides, isolation & purification, pharmacology, Peptides

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