Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization :  The STROBE-MR Statement

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<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" id="d4588008e406">Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and aim to reduce potential bias from confounding and reverse causation. </p>

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Most cited references 24

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Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.

Erik von Elm, Douglas G. Altman, Matthias Egger … (2008)

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Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Neil M. Davies, Michael V. Holmes, George Davey Smith (2019)

Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data. As with all epidemiological approaches, findings from Mendelian randomisation studies depend on specific assumptions. We provide explanations of the information typically reported in Mendelian randomisation studies that can be used to assess the plausibility of these assumptions and guidance on how to interpret findings from Mendelian randomisation studies in the context of other sources of evidence

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Mendelian Randomization.

Amit Khera, Sekar Kathiresan, Connor Emdin (2017)

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Journal

Title: JAMA

Abbreviated Title: JAMA

Publisher: American Medical Association (AMA)

ISSN (Print): 0098-7484

Publication date Created: October 26 2021

Publication date (Print): October 26 2021

Volume: 326

Issue: 16

Page: 1614

Affiliations

[1 ]Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

[2 ]Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom

[3 ]Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

[4 ]Department of Psychological Science, University of Bristol, Bristol, United Kingdom

[5 ]K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway

[6 ]Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands

[7 ]Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts

[8 ]NIHR Bristol Biomedical Research Centre, Bristol, United Kingdom

[9 ]Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France

[10 ]MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

[11 ]Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany

[12 ]JAMA, Chicago, Illinois

[13 ]Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

[14 ]Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts

[15 ]Harvard Medical School, Boston, Massachusetts

[16 ]BMJ, London, United Kingdom

[17 ]Campus Fryslân, University of Groningen, Leeuwarden, the Netherlands

[18 ]Institute of Population Health Sciences, Queen Mary, University of London, London, United Kingdom

[19 ]Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom

[20 ]Section for Molecular Genetics, Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

[21 ]Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa

[22 ]Departments of Medicine, Human Genetics, Epidemiology, & Biostatistics, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada

[23 ]Department of Twin Research and Genetic Epidemiology, King’s College London, University of London, London, United Kingdom

Article

DOI: 10.1001/jama.2021.18236

PubMed ID: 34698778

SO-VID: 159e216d-a45f-4e9c-8344-1a0685e8812f

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Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization : The STROBE-MR Statement

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Most cited references 24

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Mendelian Randomization.

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