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      Automated detection of COVID-19 using ensemble of transfer learning with deep convolutional neural network based on CT scans

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          Abstract

          Purpose

          COVID-19 has infected millions of people worldwide. One of the most important hurdles in controlling the spread of this disease is the inefficiency and lack of medical tests. Computed tomography (CT) scans are promising in providing accurate and fast detection of COVID-19. However, determining COVID-19 requires highly trained radiologists and suffers from inter-observer variability. To remedy these limitations, this paper introduces an automatic methodology based on an ensemble of deep transfer learning for the detection of COVID-19.

          Methods

          A total of 15 pre-trained convolutional neural networks (CNNs) architectures: EfficientNets(B0-B5), NasNetLarge, NasNetMobile, InceptionV3, ResNet-50, SeResnet 50, Xception, DenseNet121, ResNext50 and Inception_resnet_v2 are used and then fine-tuned on the target task. After that, we built an ensemble method based on majority voting of the best combination of deep transfer learning outputs to further improve the recognition performance. We have used a publicly available dataset of CT scans, which consists of 349 CT scans labeled as being positive for COVID-19 and 397 negative COVID-19 CT scans that are normal or contain other types of lung diseases.

          Results

          The experimental results indicate that the majority voting of 5 deep transfer learning architecture with EfficientNetB0, EfficientNetB3, EfficientNetB5, Inception_resnet_v2, and Xception has the higher results than the individual transfer learning structure and among the other models based on precision (0.857), recall (0.854) and accuracy (0.85) metrics in diagnosing COVID-19 from CT scans.

          Conclusion

          Our study based on an ensemble deep transfer learning system with different pre-trained CNNs architectures can work well on a publicly available dataset of CT images for the diagnosis of COVID-19 based on CT scans.

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          Most cited references18

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          ImageNet classification with deep convolutional neural networks

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            Dermatologist-level classification of skin cancer with deep neural networks

            Skin cancer, the most common human malignancy, is primarily diagnosed visually, beginning with an initial clinical screening and followed potentially by dermoscopic analysis, a biopsy and histopathological examination. Automated classification of skin lesions using images is a challenging task owing to the fine-grained variability in the appearance of skin lesions. Deep convolutional neural networks (CNNs) show potential for general and highly variable tasks across many fine-grained object categories. Here we demonstrate classification of skin lesions using a single CNN, trained end-to-end from images directly, using only pixels and disease labels as inputs. We train a CNN using a dataset of 129,450 clinical images—two orders of magnitude larger than previous datasets—consisting of 2,032 different diseases. We test its performance against 21 board-certified dermatologists on biopsy-proven clinical images with two critical binary classification use cases: keratinocyte carcinomas versus benign seborrheic keratoses; and malignant melanomas versus benign nevi. The first case represents the identification of the most common cancers, the second represents the identification of the deadliest skin cancer. The CNN achieves performance on par with all tested experts across both tasks, demonstrating an artificial intelligence capable of classifying skin cancer with a level of competence comparable to dermatologists. Outfitted with deep neural networks, mobile devices can potentially extend the reach of dermatologists outside of the clinic. It is projected that 6.3 billion smartphone subscriptions will exist by the year 2021 (ref. 13) and can therefore potentially provide low-cost universal access to vital diagnostic care.
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              A survey on deep learning in medical image analysis

              Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks. Concise overviews are provided of studies per application area: neuro, retinal, pulmonary, digital pathology, breast, cardiac, abdominal, musculoskeletal. We end with a summary of the current state-of-the-art, a critical discussion of open challenges and directions for future research.
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                Author and article information

                Contributors
                shalbaf@sbmu.ac.ir
                Journal
                Int J Comput Assist Radiol Surg
                Int J Comput Assist Radiol Surg
                International Journal of Computer Assisted Radiology and Surgery
                Springer International Publishing (Cham )
                1861-6410
                1861-6429
                16 November 2020
                : 1-9
                Affiliations
                [1 ]GRID grid.411463.5, ISNI 0000 0001 0706 2472, Department of Biomedical Engineering, Science and Research Branch, , Islamic Azad University, ; Tehran, Iran
                [2 ]GRID grid.411600.2, Department of Biomedical Engineering and Medical Physics, School of Medicine, , Shahid Beheshti University of Medical Sciences, ; Tehran, Iran
                [3 ]GRID grid.411748.f, ISNI 0000 0001 0387 0587, School of Electrical Engineering, , Iran University of Science and Technology, ; Tehran, Iran
                Author information
                http://orcid.org/0000-0002-1595-7281
                Article
                2286
                10.1007/s11548-020-02286-w
                7667011
                33191476
                15920975-8286-4f25-a821-3cce43094350
                © CARS 2020

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                : 23 May 2020
                : 23 October 2020
                Categories
                Original Article

                covid-19,ct,transfer learning,convolutional neural network,ensemble model

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