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Gene-expression profiles in hereditary breast cancer.
I Hedenfalk
1 ,
D Duggan ,
Y Chen ,
M Radmacher ,
M Bittner ,
R Simon ,
P Meltzer ,
B Gusterson ,
M Esteller ,
O P Kallioniemi ,
B Wilfond ,
A Borg ,
J Trent ,
M Raffeld ,
Z Yakhini ,
A Ben-Dor ,
E Dougherty ,
J Kononen ,
L Bubendorf ,
W Fehrle ,
S Pittaluga ,
S Gruvberger ,
N Loman ,
O Johannsson ,
H Olsson ,
G Sauter
Feb 22 2001
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Abstract
Many cases of hereditary breast cancer are due to mutations in either the BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often characteristic of the mutant gene. We hypothesized that the genes expressed by these two types of tumors are also distinctive, perhaps allowing us to identify cases of hereditary breast cancer on the basis of gene-expression profiles.