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      Biological function of d-tryptophan: a bibliometric analysis and review

      systematic-review

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          Abstract

          Background

          d-Tryptophan is recognised for its unique physiological properties. In this study, we aimed to explore the dynamic trends and emerging topics in d-tryptophan research to offer fresh perspectives for future studies.

          Methods

          Employing bibliometric analysis, we examined the literature on d-tryptophan indexed in the Web of Science Core Collection from January 1987 to December 2023. The “Bibliometrix” R package and CiteSpace were utilised for data processing.

          Results

          Analyses of 865 publications revealed 2209 keywords, 4068 authors, 2094 institutions, and contributors from 302 regions. The USA was at the forefront of publications concerning d-tryptophan, but the European Journal of Pharmacology, Journal of Biological Chemistry, and Journal of Medicinal Chemistry were notable for their contributions, co-citations, and impact, respectively. This literature review reveals that since 1987, studies have developed from a focus on d-tryptophan metabolism to the exploration of its functions in organic and medicinal chemistry and food science. Recent findings highlight the potential of d-tryptophan as a non-nutritional sweetener and food preservative as well as its role in inhibiting the growth of bacterial biofilms. Additionally, its immunomodulatory properties are being investigated in relation to allergic diseases. Furthermore, d-tryptophan plays a role in the therapy of atherosclerosis, osteoporosis, tuberculosis, and cancer.

          Conclusion

          The results of bibliometric analysis highlight that future research should focus on the biological functions of d-tryptophan as a food preservative and its use in immunomodulation and drug development, providing strong guidance for future research.

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          Most cited references82

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          bibliometrix : An R-tool for comprehensive science mapping analysis

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            Searching for intellectual turning points: progressive knowledge domain visualization.

            C. Chen (2004)
            This article introduces a previously undescribed method progressively visualizing the evolution of a knowledge domain's cocitation network. The method first derives a sequence of cocitation networks from a series of equal-length time interval slices. These time-registered networks are merged and visualized in a panoramic view in such a way that intellectually significant articles can be identified based on their visually salient features. The method is applied to a cocitation study of the superstring field in theoretical physics. The study focuses on the search of articles that triggered two superstring revolutions. Visually salient nodes in the panoramic view are identified, and the nature of their intellectual contributions is validated by leading scientists in the field. The analysis has demonstrated that a search for intellectual turning points can be narrowed down to visually salient nodes in the visualized network. The method provides a promising way to simplify otherwise cognitively demanding tasks to a search for landmarks, pivots, and hubs.
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              Visualizing a field of research: A methodology of systematic scientometric reviews

              Systematic scientometric reviews, empowered by computational and visual analytic approaches, offer opportunities to improve the timeliness, accessibility, and reproducibility of studies of the literature of a field of research. On the other hand, effectively and adequately identifying the most representative body of scholarly publications as the basis of subsequent analyses remains a common bottleneck in the current practice. What can we do to reduce the risk of missing something potentially significant? How can we compare different search strategies in terms of the relevance and specificity of topical areas covered? In this study, we introduce a flexible and generic methodology based on a significant extension of the general conceptual framework of citation indexing for delineating the literature of a research field. The method, through cascading citation expansion, provides a practical connection between studies of science from local and global perspectives. We demonstrate an application of the methodology to the research of literature-based discovery (LBD) and compare five datasets constructed based on three use scenarios and corresponding retrieval strategies, namely a query-based lexical search (one dataset), forward expansions starting from a groundbreaking article of LBD (two datasets), and backward expansions starting from a recently published review article by a prominent expert in LBD (two datasets). We particularly discuss the relevance of areas captured by expansion processes with reference to the query-based scientometric visualization. The method used in this study for comparing bibliometric datasets is applicable to comparative studies of search strategies.
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                Author and article information

                Contributors
                URI : https://loop.frontiersin.org/people/2131883/overviewRole: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role:
                URI : https://loop.frontiersin.org/people/1204257/overviewRole: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role:
                URI : https://loop.frontiersin.org/people/2941142/overviewRole: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role:
                Journal
                Front Microbiol
                Front Microbiol
                Front. Microbiol.
                Frontiers in Microbiology
                Frontiers Media S.A.
                1664-302X
                13 January 2025
                2024
                : 15
                : 1455540
                Affiliations
                [1] 1Department of Pediatrics, Shengjing Hospital of China Medical University , Shenyang, China
                [2] 2Department of Endocrinology, Shengjing Hospital of China Medical University , Shenyang, China
                Author notes

                Edited by: Stavros Plessas, Democritus University of Thrace, Greece

                Reviewed by: Shengqian Sun, Yantai Institute of Technology, China

                Erik Biros, James Cook University, Australia

                *Correspondence: Runyu Du, 20142190@ 123456cmu.edu.cn
                Article
                10.3389/fmicb.2024.1455540
                11770058
                39872820
                14eb405e-415d-415e-b3e6-356795229739
                Copyright © 2025 Wang, Du and Shang.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 27 June 2024
                : 30 December 2024
                Page count
                Figures: 6, Tables: 0, Equations: 0, References: 82, Pages: 13, Words: 8716
                Funding
                The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was supported by the National Natural Science Foundation of China (No. 82200930), 345 Talent Project of Shengjing hospital, and Clinical Research Project of Liaoning Diabetes Medical Nutrition Prevention Society (No. LNSTNBYXYYFZXH-RS02A).
                Categories
                Microbiology
                Systematic Review
                Custom metadata
                Food Microbiology

                Microbiology & Virology
                d-tryptophan,bibliometric analysis,d-amino acids,biological function,literature review

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