Light-based 3D bioprinting technology applied to repair and regeneration of different tissues: A rational proposal for biomedical applications

Abstract

3D bioprinting technology, a subset of 3D printing technology, is currently witnessing widespread utilization in tissue repair and regeneration endeavors. In particular, light-based 3D bioprinting technology has garnered significant interest and favor. Central to its successful implementation lies the judicious selection of photosensitive polymers. Moreover, by fine-tuning parameters such as light irradiation time, choice of photoinitiators and crosslinkers, and their concentrations, the properties of the scaffolds can be tailored to suit the specific requirements of the targeted tissue repair sites. In this comprehensive review, we provide an overview of commonly utilized bio-inks suitable for light-based 3D bioprinting, delving into the distinctive characteristics of each material. Furthermore, we delineate strategies for bio-ink selection tailored to diverse repair locations, alongside methods for optimizing printing parameters. Ultimately, we present a coherent synthesis aimed at enhancing the practical application of light-based 3D bioprinting technology in tissue engineering, while also addressing current challenges and future prospects.

Highlights

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  The choice of Photosensitive polymers is one of the key elements that determine the successful implementation of scaffold. Furthermore, Factors such as light duration and intensity, type and concentration of photoinitiator and crosslinker can change the performance of the scaffold. This review highlights the properties of different polymers, describes strategies for customizing the scaffolds and enumerates the approaches used by researchers to modification.