Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial.

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Abstract

Evidence is accumulating that early consumption is more beneficial than is delayed introduction as a strategy for primary prevention of food allergy. However, allergic reactions caused by early introduction of such solid foods have been a problematic issue. We investigated whether or not early stepwise introduction of eggs to infants with eczema combined with optimal eczema treatment would prevent egg allergy at 1 year of age.

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Author and article information

Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Jan 21 2017

Volume: 389

Issue: 10066

Affiliations

[1 ] Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development; Okura, Setagaya-Ku, Tokyo, Japan; Division of Pediatrics, Hamamatsu University School of Medicine; Handayama, Higashiku, Hamamatsu, Shizuoka, Japan.

[2 ] Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development; Okura, Setagaya-Ku, Tokyo, Japan; Division of Pediatrics, Tachikawa Sougo General Hospital; Nishiki-Cho, Tachikawa, Tokyo, Japan.

[3 ] Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development; Okura, Setagaya-Ku, Tokyo, Japan; Division of Pediatrics, Kanemura Ladies Clinic; Minami-Iriso, Hazama, Saitama, Japan.

[4 ] Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development; Okura, Setagaya-Ku, Tokyo, Japan.

[5 ] Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development; Okura, Setagaya-Ku, Tokyo, Japan; Division of Pediatrics, Oume Municipal General Hospital; Higashi-Oume, Oume, Tokyo, Japan.

[6 ] Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development; Okura, Setagaya-Ku, Tokyo, Japan; Division of Pediatrics, Tokyo Bay UrayasuIchikawa Medical Center, Pediatrics, Toudaizima, Urayasu, Chiba, Japan.

[7 ] Center for Clinical Research and Development, National Center for Child Health and Development, Okura, Setagaya, Tokyo, Japan.

[8 ] Division of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University, Tokushima, Japan.

[9 ] Department of Pediatrics and School of Public Health, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China.

[10 ] Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Okura, Setagaya, Tokyo, Japan.

[11 ] Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development; Okura, Setagaya-Ku, Tokyo, Japan. Electronic address: ohya-y@ncchd.go.jp.

Article

Publisher Item ID: S0140-6736(16)31418-0

DOI: 10.1016/S0140-6736(16)31418-0

PubMed ID: 27939035

SO-VID: 14aa5f75-b2ec-4b30-b15d-595648b1f356

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