The photoconversion of CO\(_2\) to hydrocarbons is a sustainable route to its transformation into value-added compounds and, thereby, crucial to mitigating the energy and climate crises. CuPt nanoparticles on TiO\(_2\) surfaces have been reported to show promising photoconversion efficiency. For further progress, a mechanistic understanding of the catalytic properties of these CuPt/TiO\(_2\) systems is vital. Here, we employ \textit{ab-initio} calculations, machine learning, and photocatalysis experiments to explore their configurational space and examine their reactivity and find that the interface plays a key role in stabilizing *CO\(_2\), *CO, and other CH-containing intermediates, facilitating higher activity and selectivity for methane. A bias-corrected machine-learning interatomic potential trained on density functional theory data enables efficient exploration of the potential energy surfaces of numerous CO\(_2\)@CuPt/TiO\(_2\) configurations via basin-hopping Monte Carlo simulations, greatly accelerating the study of these photocatalyst systems. Our simulations show that CO\(_2\) preferentially adsorbs at the interface, with C atom bonded to a Pt site and one O atom occupying an O-vacancy site. The interface also promotes the formation of *CH and *CH\(_2\) intermediates. For confirmation, we synthesize CuPt/TiO\(_2\) samples with a variety of compositions and analyze their morphologies and compositions using scanning electron microscopy and energy-dispersive X-ray spectroscopy, and measure their photocatalytic activity. Our computational and experimental findings qualitatively agree and highlight the importance of interface design for selective conversion of CO\(_2\) to hydrocarbons.