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      Association of Computer-Assisted Virtual Preoperative Planning With Postoperative Mortality and Complications in Older Patients With Intertrochanteric Hip Fracture

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      , MD 1 , 2 , , MD 2 , , MD 1 , , PhD 3 , , MD, PhD 1 ,
      JAMA Network Open
      American Medical Association

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          Key Points

          Question

          Is preoperative planning using computer-assisted virtual surgical technology associated with decreases in the risks of all-cause 90-day mortality and postoperative complications among older patients with intertrochanteric hip fractures?

          Findings

          In this cohort study of 1221 older patients with intertrochanteric hip fractures, the use of computer-assisted virtual preoperative planning among a propensity score–matched cohort was associated with a lower incidence of 90-day mortality and postoperative complications compared with the use of conventional preoperative planning.

          Meaning

          This study’s findings suggest that preoperative planning using computer-assisted virtual surgical technology for older patients with intertrochanteric hip fractures is associated with decreases in the risks of all-cause 90-day mortality and postoperative complications.

          Abstract

          Importance

          The outcomes of surgical treatment in patients with intertrochanteric hip fractures are unsatisfactory. Computer-assisted virtual preoperative planning may provide an opportunity to solve this treatment dilemma. Virtual preoperative planning is a technique based on dynamic 3-dimensional computed tomographic imaging, which allows precise evaluation of fracture details and simulation of reduction of fracture and internal fixation procedures before surgery is performed.

          Objective

          To evaluate the association of computer-assisted virtual preoperative planning with the risk of 90-day all-cause mortality and postoperative complications.

          Design, Setting, and Participants

          This retrospective cohort study was conducted from using patient data from a level 1 trauma center database. A total of 1445 patients 65 years and older with intertrochanteric hip fractures between January 1, 2009, and March 31, 2018, were identified and divided into 2 cohorts: 558 patients received computer-assisted virtual preoperative planning (virtual planning group), and 887 patients received conventional preoperative planning (conventional planning group). Of the initial 1445 patients, 224 patients (93 patients in the virtual planning group and 131 patients in the conventional planning group) were excluded, resulting in 1221 patients in the final cohort. Data were analyzed from April 5 to October 5, 2019.

          Exposures

          Computer-assisted virtual vs conventional surgical preoperative planning.

          Main Outcomes and Measures

          Primary outcomes were 90-day all-cause mortality and postoperative complications (including myocardial infarction, heart failure, stroke, kidney failure, and sepsis). Secondary outcomes were 90-day outpatient visits, hospital readmissions, and reoperations.

          Results

          Among 1221 patients who underwent hip surgery, the mean (SD) age was 73.2 (12.3) years, and 927 patients (75.9%) were women. A total of 465 patients (38.1%) were in the virtual planning group and 756 patients (61.9%) were in the conventional planning group. Among the 814 patients (407 patients in each group) who were matched by propensity score, the virtual planning group had a lower incidence of mortality (37 patients [9.1%] vs 55 patients [13.5%]; hazard ratio [HR], 0.64; 95% CI, 0.41-0.99; P = .04) and postoperative complications (25 patients [6.1%] vs 44 patients [10.8%]; HR, 0.54; 95% CI, 0.32-0.90; P = .02) compared with the conventional planning group. The incidence of outpatient visits was not substantially different in the virtual planning group (1.51 incidents per 30 person-days) compared with the conventional planning group (1.48 incidents per 30 person-days; incidence rate ratio [IRR], 0.90; 95% CI, 0.49-1.68; P = .75). Similar results were observed for the rate of hospital readmissions (0.99 incidents per 30 person-days in the virtual planning group and 1.01 incidents per 30 person-days in the conventional planning group; IRR, 0.91; 95% CI, 0.49-1.67; P = .76). However, the rate of reoperations was lower in the virtual planning group (0.76 incidents per 30 person-days) than in the conventional planning group (0.97 incidents per 30 person-days; IRR, 0.41; 95% CI, 0.22-0.76; P = .01).

          Conclusions and Relevance

          Among older patients with intertrochanteric hip fractures, computer-assisted virtual preoperative planning was associated with decreases in the risks of all-cause 90-day mortality, postoperative complications, and reoperations compared with conventional preoperative planning.

          Abstract

          This cohort study uses data from a level 1 trauma center database to evaluate the association of computer-assisted virtual preoperative planning with the risk of 90-day all-cause mortality and postoperative complications among older patients with intertrochanteric hip fractures in China.

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          Most cited references15

          • Record: found
          • Abstract: found
          • Article: not found

          Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery.

          Of the 200 million adults worldwide who undergo noncardiac surgery each year, more than 1 million will die within 30 days. To determine the relationship between the peak fourth-generation troponin T (TnT) measurement in the first 3 days after noncardiac surgery and 30-day mortality. A prospective, international cohort study that enrolled patients from August 6, 2007, to January 11, 2011. Eligible patients were aged 45 years and older and required at least an overnight hospital admission after having noncardiac surgery. Patients' TnT levels were measured 6 to 12 hours after surgery and on days 1, 2, and 3 after surgery. We undertook Cox regression analysis in which the dependent variable was mortality until 30 days after surgery, and the independent variables included 24 preoperative variables. We repeated this analysis, adding the peak TnT measurement during the first 3 postoperative days as an independent variable and used a minimum P value approach to determine if there were TnT thresholds that independently altered patients' risk of death. A total of 15,133 patients were included in this study. The 30-day mortality rate was 1.9% (95% CI, 1.7%-2.1%). Multivariable analysis demonstrated that peak TnT values of at least 0.02 ng/mL, occurring in 11.6% of patients, were associated with higher 30-day mortality compared with the reference group (peak TnT ≤ 0.01 ng/mL): peak TnT of 0.02 ng/mL (adjusted hazard ratio [aHR], 2.41; 95% CI, 1.33-3.77); 0.03 to 0.29 ng/mL (aHR, 5.00; 95% CI, 3.72-6.76); and 0.30 ng/mL or greater (aHR, 10.48; 95% CI, 6.25-16.62). Patients with a peak TnT value of 0.01 ng/mL or less, 0.02, 0.03-0.29, and 0.30 or greater had 30-day mortality rates of 1.0%, 4.0%, 9.3%, and 16.9%, respectively. Peak TnT measurement added incremental prognostic value to discriminate those likely to die within 30 days for the model with peak TnT measurement vs without (C index = 0.85 vs 0.81; difference, 0.4; 95% CI, 0.2-0.5; P < .001 for difference between C index values). The net reclassification improvement with TnT was 25.0% (P < .001). Among patients undergoing noncardiac surgery, the peak postoperative TnT measurement during the first 3 days after surgery was significantly associated with 30-day mortality.
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            • Record: found
            • Abstract: not found
            • Article: not found

            Management of Acute Hip Fracture

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              • Record: found
              • Abstract: found
              • Article: not found

              Association of timing of surgery for hip fracture and patient outcomes.

              Previous studies of surgical timing in patients with hip fracture have yielded conflicting findings on mortality and have not focused on functional outcomes. To examine the association of timing of surgical repair of hip fracture with function and other outcomes. Prospective cohort study including analyses matching cases of early ( 24 hours) surgery with propensity scores and excluding patients who might not be candidates for early surgery. Four hospitals in the New York City metropolitan area. A total of 1206 patients aged 50 years or older admitted with hip fracture over 29 months, ending December 1999. Function (using the Functional Independence Measure), survival, pain, and length of stay (LOS). Of the patients treated with surgery (n = 1178), 33.8% had surgery within 24 hours. Earlier surgery was not associated with improved mortality (hazard ratio, 0.75; 95% confidence interval [CI], 0.52-1.08) or improved locomotion (difference of -0.04 points; 95% CI, -0.49 to 0.39). Earlier surgery was associated with fewer days of severe and very severe pain (difference of -0.22 days; 95% CI, -0.41 to -0.03) and shorter LOS by 1.94 days (P<.001), but postoperative pain and LOS after surgery did not differ. Analyses with propensity scores yielded similar results. When the cohort included only patients who were medically stable at admission and therefore eligible for early surgery, the results were unchanged except that early surgery was associated with fewer major complications (odds ratio, 0.26; 95% CI, 0.07-0.95). Early surgery was not associated with improved function or mortality, but it was associated with reduced pain and LOS and probably major complications among patients medically stable at admission. Additional research is needed on whether functional outcomes may be improved. In the meantime, patients with hip fracture who are medically stable should receive early surgery when possible.
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                Author and article information

                Journal
                JAMA Netw Open
                JAMA Netw Open
                JAMA Netw Open
                JAMA Network Open
                American Medical Association
                2574-3805
                10 August 2020
                August 2020
                10 August 2020
                : 3
                : 8
                : e205830
                Affiliations
                [1 ]Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
                [2 ]Department of Orthopedic Trauma, East Hospital, Tongji University School of Medicine, Shanghai, China
                [3 ]Department of Biostatistics, School of Public Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, Southern Medical University, Guangdong, Guangzhou, China
                Author notes
                Article Information
                Accepted for Publication: March 21, 2020.
                Published: August 10, 2020. doi:10.1001/jamanetworkopen.2020.5830
                Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Jia X et al. JAMA Network Open.
                Corresponding Author: Yanxi Chen, MD, PhD, Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China ( cyxtongji@ 123456126.com ).
                Author Contributions: Drs Jia and Chen had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
                Concept and design: All authors.
                Acquisition, analysis, or interpretation of data: All authors.
                Drafting of the manuscript: Jia, Zhang, Qiang, Chen.
                Critical revision of the manuscript for important intellectual content: Jia, Zhang, Wu, Chen.
                Statistical analysis: All authors.
                Administrative, technical, or material support: Jia, Qiang, Wu, Chen.
                Supervision: Jia, Zhang, Wu, Chen.
                Conflict of Interest Disclosures: None reported.
                Additional Contributions: Kanu Okike, MD, MPH, of the Kaiser Moanalua Medical Center in Hawaii provided valuable suggestions for the revision of this article. Qinghui Han, MD, of the Tongji University School of Medicine assisted with data collection. The contributors did not receive any compensation for their assistance.
                Article
                zoi200271
                10.1001/jamanetworkopen.2020.5830
                7417968
                32777058
                141a7250-4ef5-4c1a-b39e-926d5d3c625d
                Copyright 2020 Jia X et al. JAMA Network Open.

                This is an open access article distributed under the terms of the CC-BY License.

                History
                : 5 November 2019
                : 21 March 2020
                Categories
                Research
                Original Investigation
                Online Only
                Orthopedics

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