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      Myopericarditis Following Use of Selective Androgen Receptor Modifier “RAD-140”

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          Abstract

          We report the case of a 16-year-old boy who had myopericarditis following the first dose of a selective androgen receptor modulator called Testolone (“RAD-140”). These drugs are widely abused by physically active young adults; however, the drugs’ side effects, which can be life-threatening, are not well characterized.

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          Social Media, Body Image and Resistance Training: Creating the Perfect ‘Me’ with Dietary Supplements, Anabolic Steroids and SARM’s

          Luuk Hilkens, Maarten JLF Cruyff, Liesbeth Woertman … (2021)
          Background Few studies have assessed the use of dietary supplements, anabolic androgenic steroids (AAS) and selective androgen receptor modulators (SARM) in male gym users. The comparison of physical appearance with others on social media and the exposure to fitness-related content on social media (i.e., image-centric social media use) may have a profound role in using these compounds due to its role in creating negative body images in male gym users. Objective Provide contemporary data on the use of dietary supplements, AAS and SARM among young male gym users, and test the hypothesis that social media is associated with the use of dietary supplements, AAS and SARM, as a result of a negative body image. Methods In this cross-sectional study, conducted in the Netherlands, male gym users ( N  = 2269; 24 ± 6 years) completed an online questionnaire including self-reported measures regarding resistance training participation, image-centric social media use, dietary supplement intake, and body image. The prevalence of AAS and SARM use was assessed with randomized response, a technique to ask sensitive questions indirectly. Results Of all participants, 83% used ergogenic dietary supplements (mainly protein and creatine), and an estimated 9 versus 2.7% had ever used AAS versus SARM. Image-centric social media use was positively associated with the use of dietary supplements ( r  = .26; p  < 0.01) and AAS ( p  < 0.05), but not SARM. Image-centric social media use was associated with a more dissatisfied body image ( r  = .34; p  < 0.01). Body image did not mediate the relationship between image-centric social media use and the use of doping compounds. Conclusions The use of dietary supplements in young male gym users is exorbitant, with the use of AAS and SARM being substantial. Image-centric social media use is positively associated with the use of dietary supplements and AAS. Supplementary Information The online version contains supplementary material available at 10.1186/s40798-021-00371-1.
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            Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033)

            Mary Barbara, Sadhna Dhingra, Ayse Mindikoglu (2020)
            ABSTRACT We report a 52-year-old man who developed drug-induced liver injury after taking Alpha Bolic (contains RAD-140) and Alpha Elite (contains both RAD-140 and LGD-4033) supplements. Liver biopsy demonstrated diffuse centrilobular canalicular cholestasis, prominent ductular reaction, and mild lobular inflammation with rare non-necrotizing epithelioid granuloma suggestive of drug-induced liver injury. Liver enzymes returned to normal levels approximately 3 months after the patient stopped both supplements. We present the mechanism of drug-induced liver injury associated with 2 selective androgen receptor modulators, including RAD-140 and LGD 4033.
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              Performance- and image-enhancing drug use in the community: use prevalence, user demographics and the potential role of wastewater-based epidemiology

              Katja M Shimko, Timothy Piatkowski, Kevin Thomas … (2021)
              Performance- and image-enhancing drug (PIED) misuse is a significant public health issue. Currently, seizure data, surveys, anti-doping testing, and needle service provider data are used to estimate PIED use in populations. These methods are time consuming, single point-in-time measurements that often consist of small sample sizes and do not truly capture PIED prevalence. Wastewater-based epidemiology (WBE) has been used globally to assess and monitor licit and illicit drug consumption within the general community. This method can objectively cover large populations as well as specific subpopulations (gyms, music festivals, prisons), and has potential as a complementary monitoring method for PIED use. Information obtained through WBE could be used to aid public health authorities in developing targeted prevention and education programmes. Research on PIED analysis in wastewater is limited and presents a significant gap in the literature. The focus is on anabolic steroids, and one steroid alternative currently growing in popularity; selective androgenic receptor modulators. This encompasses medical uses, addiction, prevalence, user typology, and associated public health implications. An overview of WBE is described including its benefits, limitations and potential as a monitoring method for PIED use. A summary of previous work in this field is presented. Finally, we summarise gaps in the literature, future perspectives, and recommendations for monitoring PIEDs in wastewater.
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                Author and article information

                Contributors
                Mehar Hoda
                Journal
                Journal ID (nlm-ta): JACC Case Rep
                Journal ID (iso-abbrev): JACC Case Rep
                Title: JACC Case Reports
                Publisher: Elsevier
                ISSN (Electronic): 2666-0849
                Publication date PMC-release: 07 August 2024
                Publication date Collection: 07 August 2024
                Publication date (Electronic): 07 August 2024
                Volume: 29
                Issue: 15
                Electronic Location Identifier: 102423
                Affiliations
                [a ]West Virginia University School of Medicine, Morgantown, West Virginia, USA
                [b ]Section of Pediatric Cardiology and Electrophysiology, Department of Pediatrics, West Virginia University Children’s Hospital, Morgantown, West Virginia, USA
                [c ]Section of Pediatric Cardiology, Department of Pediatrics, West Virginia University, Morgantown, West Virginia, USA
                Author notes
                [∗ ] Address for correspondence: Dr Mehar Hoda, Section of Pediatric Cardiology, Department of Pediatrics, WVU Medicine Children’s Hospital, 64 Medical Center Drive, Robert C. Byrd Health Science Center, PO Box 9214, Morgantown, West Virginia 26506-9214, USA. mehoda@ 123456hsc.wvu.edu
                Article
                Publisher Item ID: S2666-0849(24)00216-X Publisher ID: 102423
                DOI: 10.1016/j.jaccas.2024.102423
                PMC ID: 11328744
                SO-VID: 1397cf4f-1d58-465e-ac60-e9209acc1acb
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 19 February 2024
                Date revision received : 23 May 2024
                Date accepted : 29 May 2024
                Categories
                Subject: Heart Failure and Cardiomyopathies
                Subject: Case Report: Clinical Case

                Keywords: myocarditis,rad-140,selective androgen receptor,testolone modulator
                Data availability:
                Keywords: myocarditis, rad-140, selective androgen receptor, testolone modulator

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