MALIGNANT TRANSFORMATION OF ACTINIC KERATOSES TO SQUAMOUS CELL CARCINOMA IN AN ALBINO

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Abstract

A 25-year-old male, who was a known case of oculocutaneous albinism presented to us with right inguinal swellings of six months' duration. He gave a preceding history of a similar lump in the right thigh, which was excised at the Chennai Government Hospital. He was diagnosed to have oculocutaneous albinism with actinic keratoses, with multiple squamous cell carcinomas (with metastatic deposits in the right inguinal region) and cutaneous horns. The case is reported to highlight preventive aspects in the management of albinos.

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Most cited references 9

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Reduction of solar keratoses by regular sunscreen use.

Sandra C. Thompson, Damien Jolley, Robin Marks (1993)

The incidence of and mortality from skin cancer are increasing in many countries. In view of the added concern about ozone depletion, many organizations are promoting the regular use of sunscreens to prevent skin cancer, despite the absence of evidence that these products have this effect. Solar (actinic) keratosis is a precursor of squamous-cell carcinoma of the skin. We conducted a randomized, controlled trial of the effect on solar keratoses of daily use of a broad-spectrum sunscreen cream with a sun-protection factor of 17 in 588 people 40 years of age or older in Australia during one summer (September 1991 to March 1992). The subjects applied either a sunscreen cream or the base cream minus the active ingredients of the sunscreen to the head, neck, forearms, and hands. The mean number of solar keratoses increased by 1.0 per subject in the base-cream group and decreased by 0.6 in the sunscreen group (difference, 1.53; 95 percent confidence interval, 0.81 to 2.25). The sunscreen group had fewer new lesions (rate ratio, 0.62; 95 percent confidence interval, 0.54 to 0.71) and more remissions (odds ratio, 1.53; 95 percent confidence interval, 1.29 to 1.80) than the base-cream group. There was a dose-response relation: the amount of sunscreen cream used was related to both the development of new lesions and the remission of existing ones. Regular use of sunscreens prevents the development of solar keratoses and, by implication, possibly reduces the risk of skin cancer in the long-term.

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Actinic damage and skin cancer in albinos in northern Tanzania: findings in 164 patients enrolled in an outreach skin care program.

Donald Lookingbill, Georgia Lookingbill, Barbara Leppard (1995)

Persons with albinism are particularly vulnerable to the deleterious effects of UV light on their skin. We obtained histories and performed skin examinations on 164 albino patients living in equatorial Africa to determine their sun exposure, sun protection, and sun damage. Many patients did not wear hats and most wore short-sleeved shirts. Except for four infants, all patients had sunburned skin. Actinic cheilitis, actinic keratoses, and skin cancers were detected in many patients. Sun protection methods will be important for prevention of skin damage in albino patients.

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The actinic (solar) keratosis: a 21st-century perspective.

Lisa Fu, Clay J Cockerell (2002)

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Author and article information

Journal

Journal ID (nlm-ta): Indian J Dermatol

Journal ID (publisher-id): IJD

Title: Indian Journal of Dermatology

Publisher: Medknow Publications (India )

ISSN (Print): 0019-5154

ISSN (Electronic): 1998-3611

Publication date (Print): Jan-Mar 2009

Volume: 54

Issue: 1

Pages: 46-48

Affiliations

From the Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India

Author notes

Address for correspondence: Dr. Devinder Mohan Thappa, Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry - 605 006, India. E-mail: dmthppa@ 123456gmail.com ; dmthappa@ 123456satyam.net.in

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Publisher ID: IJD-54-46

DOI: 10.4103/0019-5154.48986

PMC ID: 2800870

PubMed ID: 20049269

SO-VID: 133ae11e-2e9f-4a45-808b-d2e321108be9

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

MALIGNANT TRANSFORMATION OF ACTINIC KERATOSES TO SQUAMOUS CELL CARCINOMA IN AN ALBINO

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Abstract

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Karger: Dermatology

Most cited references 9

Reduction of solar keratoses by regular sunscreen use.

Actinic damage and skin cancer in albinos in northern Tanzania: findings in 164 patients enrolled in an outreach skin care program.

The actinic (solar) keratosis: a 21st-century perspective.

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