In situ formation of large pore silica-MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging.

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Abstract

A cancer cell-specific, endogenous H+/H2O2-activated, and O2 self-sufficient nanocomposite is engineered and characterized. Such NPs, with good biocompatibility and rapid response to intracellular H+/H2O2, have demonstrated improved therapeutic effects in targeted cancer cells and activated MR signals in vitro, providing a promising strategy for effective PDT against tumor hypoxia.

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Journal

Journal ID (iso-abbrev): Chem Commun (Camb)

Title: Chemical communications (Cambridge, England)

Publisher: Royal Society of Chemistry (RSC)

ISSN (Electronic): 1364-548X

ISSN (Print): 1359-7345

Publication date (Electronic): Mar 25 2018

Volume: 54

Issue: 24

Affiliations

[1 ] State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210023, China. jjzhu@nju.edu.cn.

[2 ] State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210023, China. jjzhu@nju.edu.cn and School of Chemistry and Life Science, Nanjing University Jinling College, Nanjing 210089, China.

[3 ] State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210023, China. jjzhu@nju.edu.cn and The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, China.

Article

DOI: 10.1039/c7cc09532e

PubMed ID: 29388991

SO-VID: 12ff087d-4c61-4453-a8b7-f83029d7ceeb

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