Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology.

Burt, Olivia; Johnston, Keira J A; Graham, Nicholas J; Cullen, Breda; Lyall, Donald M.; Lyall, Laura M.; Pell, Jill P.; Ward, Joey; Smith, Daniel J; Strawbridge, Rona J.

doi:10.3390/genes12081194

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Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology.

Author(s): Olivia Burt ¹ , Keira J A Johnston ¹ ^, ² ^, ³ , Nicholas Graham ¹ , Breda Cullen ¹ , Donald M Lyall ¹ , Laura M Lyall ¹ , Jill P Pell ¹ , Joey Ward ¹ , Daniel J Smith ¹ , Rona J Strawbridge ¹ ^, ⁴ ^, ⁵

Publication date (Electronic): Jul 31 2021

Journal: Genes

Publisher: MDPI AG

Keywords: ASTN2, BMI, anhedonia, blood pressure, cardiovascular disease, central obesity, metabolic disease, mood instability, neuroticism, psychiatric illness

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Abstract

The link between cardiometabolic and psychiatric illness has long been attributed to human behaviour, however recent research highlights shared biological mechanisms. The ASTN2 locus has been previously implicated in psychiatric and cardiometabolic traits, therefore this study aimed to systematically investigate the genetic architecture of ASTN2 in relation to a wide range of relevant traits.

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Journal ID (iso-abbrev): Genes (Basel)

Title: Genes

Publisher: MDPI AG

ISSN (Electronic): 2073-4425

ISSN (Print): 2073-4425

Publication date (Electronic): Jul 31 2021

Volume: 12

Issue: 8

Affiliations

[1 ] Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.

[2 ] Division of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, UK.

[3 ] School of Life Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

[4 ] Health Data Research UK, Glasgow G12 8QQ, UK.

[5 ] Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, 17177 Stockholm, Sweden.

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Publisher Item ID: genes12081194

DOI: 10.3390/genes12081194

PMC ID: 8391428

PubMed ID: 34440368

SO-VID: 124854d8-8632-411a-a612-7ade96120ef4

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Keywords: ASTN2,psychiatric illness,BMI,neuroticism,mood instability,metabolic disease,central obesity,cardiovascular disease,blood pressure,anhedonia

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Keywords: ASTN2, psychiatric illness, BMI, neuroticism, mood instability, metabolic disease, central obesity, cardiovascular disease, blood pressure, anhedonia

Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology.

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