MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis

Abstract

Background

To identify predictive value of apparent diffusion coefficient (ADC) values and magnetic resonance imaging (MRI)-based radiomics for all recurrences in patients with endometrial carcinoma (EC).

Methods

One hundred and seventy-four EC patients who were treated with operation and followed up in our institution were retrospectively reviewed, and the patients were divided into training and test group. Baseline clinicopathological features and mean ADC (ADC _mean), minimum ADC (ADC _min), and maximum ADC (ADC _max) were analyzed. Radiomic parameters were extracted on T2 weighted images and screened by logistic regression, and then a radiomics signature was developed to calculate the radiomic score (radscore). In training group, Kaplan–Meier analysis was performed and a Cox regression model was used to evaluate the correlation between clinicopathological features, ADC values and radscore with recurrence, and verified in the test group.

Results

ADC _mean showed inverse correlation with recurrence, while radscore was positively associated with recurrence. In univariate analyses, FIGO stage, pathological types, myometrial invasion, ADC _mean, ADC _min and radscore were associated with recurrence. In the training group, multivariate Cox analysis showed that pathological types, ADC _mean and radscore were independent risk factors for recurrence, which were verified in the test group.

Conclusions

ADC _mean value and radscore were independent predictors of recurrence of EC, which can supplement prognostic information in addition to clinicopathological information and provide basis for individualized treatment and follow-up plan.

Supplementary Information

The online version contains supplementary material available at 10.1186/s12885-021-08988-x.