Bibliometric and visual analysis of microglia-related neuropathic pain from 2000 to 2021

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Abstract

Background

Microglia has gradually gained researchers’ attention in the past few decades and has shown its promising prospect in treating neuropathic pain. Our study was performed to comprehensively evaluate microglia-related neuropathic pain via a bibliometric approach.

Methods

We retrospectively reviewed publications focusing on microglia-related neuropathic pain from 2000 to 2021 in WoSCC. VOS viewer software and CiteSpace software were used for statistical analyses.

Results

A total of 2,609 articles were finally included. A steady increase in the number of relevant publications was observed in the past two decades. China is the most productive country, while the United States shares the most-cited and highest H-index country. The University of London, Kyushu University, and the University of California are the top 3 institutions with the highest number of publications. Molecular pain and Pain are the most productive and co-cited journals, respectively. Inoue K (Kyushu University) is the most-contributed researcher and Ji RR (Duke University) ranks 1st in both average citations per article and H-index. Keywords analyses revealed that pro-inflammatory cytokines shared the highest burst strength. Sex differences, neuroinflammation, and oxidative stress are the emerging keywords in recent years.

Conclusion

In the field of microglia-related neuropathic pain, China is the largest producer and the United States is the most influential country. The signaling communication between microglia and neurons has continued to be vital in this field. Sexual dimorphism, neuroinflammation, and stem-cell therapies might be emerging trends that should be closely monitored.

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Most cited references 132

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Is Open Access

Software survey: VOSviewer, a computer program for bibliometric mapping

Nees Jan van Eck, Ludo Waltman (2011)

We present VOSviewer, a freely available computer program that we have developed for constructing and viewing bibliometric maps. Unlike most computer programs that are used for bibliometric mapping, VOSviewer pays special attention to the graphical representation of bibliometric maps. The functionality of VOSviewer is especially useful for displaying large bibliometric maps in an easy-to-interpret way. The paper consists of three parts. In the first part, an overview of VOSviewer’s functionality for displaying bibliometric maps is provided. In the second part, the technical implementation of specific parts of the program is discussed. Finally, in the third part, VOSviewer’s ability to handle large maps is demonstrated by using the program to construct and display a co-citation map of 5,000 major scientific journals.

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A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.

Hadas Keren‐Shaul, Amit Spinrad, Assaf Weiner … (2017)

Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD onset and progression has been challenging. Using transcriptional single-cell sorting, we comprehensively map all immune populations in wild-type and AD-transgenic (Tg-AD) mouse brains. We describe a novel microglia type associated with neurodegenerative diseases (DAM) and identify markers, spatial localization, and pathways associated with these cells. Immunohistochemical staining of mice and human brain slices shows DAM with intracellular/phagocytic Aβ particles. Single-cell analysis of DAM in Tg-AD and triggering receptor expressed on myeloid cells 2 (Trem2)(-/-) Tg-AD reveals that the DAM program is activated in a two-step process. Activation is initiated in a Trem2-independent manner that involves downregulation of microglia checkpoints, followed by activation of a Trem2-dependent program. This unique microglia-type has the potential to restrict neurodegeneration, which may have important implications for future treatment of AD and other neurodegenerative diseases. VIDEO ABSTRACT.

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CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature

Chaomei Chen (2006)

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Author and article information

Contributors

Shun-Bai Zhang: URI : https://loop.frontiersin.org/people/2165588/overview

Hai-Hong Zhang: URI : https://loop.frontiersin.org/people/2170480/overview

Journal

Journal ID (nlm-ta): Front Mol Neurosci

Journal ID (iso-abbrev): Front Mol Neurosci

Journal ID (publisher-id): Front. Mol. Neurosci.

Title: Frontiers in Molecular Neuroscience

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1662-5099

Publication date (Electronic): 18 May 2023

Publication date Collection: 2023

Volume: 16

Electronic Location Identifier: 1142852

Affiliations

[1] ¹Lanzhou University Second Hospital , Lanzhou, China

[2] ²Orthopaedics Key Laboratory of Gansu Province , Lanzhou, China

Author notes

Edited by: Silke Neumann, University of Otago, New Zealand

Reviewed by: Yayun Wang, Air Force Medical University, China; Livio Luongo, University of Campania Luigi Vanvitelli, Italy

*Correspondence: Hai-Hong Zhang, zhanghaih_1968@ 123456163.com

Article

DOI: 10.3389/fnmol.2023.1142852

PMC ID: 10233022

PubMed ID: 37273906

SO-VID: 11f0c435-f087-464d-86d4-e288ebe77c33

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 12 January 2023

Date accepted : 28 April 2023

Page count

Figures: 8, Tables: 9, Equations: 0, References: 132, Pages: 20, Words: 15200

Custom metadata

section-at-acceptance Pain Mechanisms and Modulators

ScienceOpen disciplines: Neurosciences

Keywords: microglia,neuropathic pain,bibliometric analysis,citespace,vosviewer,visual analysis

Data availability:

ScienceOpen disciplines: Neurosciences

Keywords: microglia, neuropathic pain, bibliometric analysis, citespace, vosviewer, visual analysis

Bibliometric and visual analysis of microglia-related neuropathic pain from 2000 to 2021

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Abstract

Background

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Conclusion

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Behavioral phenotypization of a mouse model for Alzheimer's: PDAPP = Tg(APPV717F)109Ili

Most cited references 132

Software survey: VOSviewer, a computer program for bibliometric mapping

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.

CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature

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