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      Fixed Drug Eruption Due to Ornidazole

      case-report
      Indian Journal of Dermatology
      Medknow Publications & Media Pvt Ltd
      Fixed drug eruption, ornidazole, provocation test

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          Abstract

          A 56-year-old male developed an ulcer on his glans penis and mucosae of upper and lower lips 3 days after taking ofloxacin, cephalexin, and ornidazole. Clinically, a provisional diagnosis of fixed drug eruption was made. The causative drug was confirmed by an oral provocation test which triggered a reactivation of all lesions only with ornidazole.

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          Most cited references16

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          Fixed drug eruption: pathogenesis and diagnostic tests.

          Fixed drug eruption is a simplified disease model for elucidating the mechanism(s) of how skin inflammation is induced by skin-resident T cells. In this review, we focus on how the presence of intraepidermal CD8+T cells resident in the fixed drug eruption lesions can provide exciting new clues to our understanding of pathomechanisms of inflammatory skin diseases. Intraepidermal CD8+T cells with an effector-memory phenotype resident in fixed drug eruption lesions have a major contributing role in the development of localized tissue damage. Activation of these CD8+T cells is sufficient for triggering the lesion, however, but not sufficient to cause extensive tissue damage observed in the fully evolved lesions; additional recruitment of CD4+ and CD8+T cells to a specific tissue site would also contribute to the late stage of lesion development. The influx of regulatory T cells into the epidermis observed in fully evolved lesions would serve to limit harmful immune reactions. Consistent with this, positive patch test reactions are only observed at the site of previous lesions harboring significant numbers of intraepidermal CD8+T cells. Intraepidermal CD8+T cells may represent double-edged swords of the skin immune system with protective and destructive capacity.
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            Adverse drug reactions in the orofacial region.

            A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.
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              Fixed drug eruption. A brief review.

              Fixed drug eruption (FDE) is a distinctive variant of drug-induced dermatoses with characteristic recurrence at the same site of the skin or mucous membranes. The clinical and laboratory features of FDE are reviewed herein and possible pathogenetic mechanisms are discussed.
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                Author and article information

                Journal
                Indian J Dermatol
                Indian J Dermatol
                IJD
                Indian Journal of Dermatology
                Medknow Publications & Media Pvt Ltd (India )
                0019-5154
                1998-3611
                Nov-Dec 2014
                : 59
                : 6
                : 635
                Affiliations
                [1] From the Department of Dermatology, Indraprastha Apollo Hospital Sarita Vihar, New Delhi, India
                Author notes
                Address for correspondence: Dr. Ramji Gupta, M-54, Jal Vihar Road, Lajpat Nagar-II, New Delhi - 110 024, India. E-mail: drramjigupta@ 123456yahoo.co.in
                Article
                IJD-59-635a
                10.4103/0019-5154.143591
                4248543
                25484435
                11b31278-1a90-4dcb-bf75-21a536118f3d
                Copyright: © Indian Journal of Dermatology

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : August 2012
                : September 2012
                Categories
                E-IJD Case Report

                Dermatology
                fixed drug eruption,ornidazole,provocation test
                Dermatology
                fixed drug eruption, ornidazole, provocation test

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