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Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial.
Luisa L Villa
1 ,
Ronaldo L R Costa ,
Carlos A Petta ,
Rosires P Andrade ,
Kevin A Ault ,
Anna R Giuliano ,
Cosette M Wheeler ,
Laura A Koutsky ,
Christian Malm ,
Matti Lehtinen ,
Finn Egil Skjeldestad ,
Sven-Eric Olsson ,
Margareta Steinwall ,
Darron R Brown ,
Robert J Kurman ,
Brigitte M Ronnett ,
Mark H Stoler ,
Alex Ferenczy ,
Diane M Harper ,
Gretchen M Tamms ,
Jimmy Yu ,
Lisa Lupinacci ,
Radha Railkar ,
Frank J Taddeo ,
Kathrin U Jansen ,
Mark T Esser ,
Heather L Sings ,
Alfred J Saah ,
Eliav Barr
May 2005
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Abstract
A randomised double-blind placebo-controlled phase II study was done to assess the efficacy of a prophylactic quadrivalent vaccine targeting the human papillomavirus (HPV) types associated with 70% of cervical cancers (types 16 and 18) and with 90% of genital warts (types 6 and 11).