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      Anatomical, phytochemical and histochemical study of Solidago chilensis Meyen

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          Abstract

          ABSTRACT Solidago chilensis Meyen, belonging to the family Asteraceae, is a plant native to South America and the only representative of the genus in Brazil. This species is popularly known as “arnica” and is used to treat bruises, muscle pain and inflammation. The objective of this work was to contribute to the pharmacognostic standardization of S. chilensis. Cross-sections were obtained, by freehand, for microscopic analysis of root, stem and leaf; for these parts of the plant maceration was also performed according to the method of Jeffrey. For the leaf were still made paradermal sections, scanning electron microscopy analysis, phytochemical and histochemical tests. Thus, it was determined anatomical features useful for diagnosis of the species which, together with identification of the chemical compounds and its histolocalization, provides support to their quality control.

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          Bemerkungenzur Doppelfärbung Astrablau-Safranin

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            Medicinal plants popularly used in the Brazilian Tropical Atlantic Forest.

            A survey of medicinal plants used by rural and urban inhabitants of the three cities of the Tropical Atlantic Forest, Region of Vale do Ribeira, State of São Paulo, Brazil was performed by means of 200 interviews with medicinal plant users and extractors and, traditional healers. One hundred fourteen herbal remedies were recorded and the following information reported: Latin, vernacular and English names, plant part used, forms of preparation and application of the herbal remedies, medicinal or food uses, areas of plant collection, economic importance (when available) and other data.
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              Traditional use and safety of herbal medicines

              In the European Union, traditional herbal medicines that are regarded as "acceptably safe, albeit not having a recognized level of efficacy" fit into a special category of drugs ("traditional herbal medicine products") for which requirements of non-clinical and clinical studies are less rigorous. A regulation proposal published by the Brazilian National Health Surveillance (Anvisa) defines a similar drug category ("traditional phytotherapeutic products") for registration purposes. Regarding herbal medicines, both agencies seem to be lenient regarding proof of efficacy, and consider long-standing folk use as evidence of safety and a waiver of a thorough toxicological evaluation. Nonetheless, several herbal products and constituents with a long history of folk usage are suspected carcinogenic and/or hepatotoxic. Herbal products have also been shown to inhibit and/or induce drug-metabolizing enzymes. Since herbal medicines are often used in conjunction with conventional drugs, kinetic and clinical interactions are a cause for concern. A demonstration of the safety of herbal medicines for registration purposes should include at least in vitroand in vivogenotoxicity assays, long-term rodent carcinogenicity tests (for drugs intended to be continuously used for > 3 months or intermittently for > 6 months), reproductive and developmental toxicity studies (for drugs used by women of childbearing age), and investigation of the effects on drug-metabolizing enzymes.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                aabc
                Anais da Academia Brasileira de Ciências
                An. Acad. Bras. Ciênc.
                Academia Brasileira de Ciências (Rio de Janeiro, RJ, Brazil )
                0001-3765
                1678-2690
                June 2017
                : 90
                : 2 suppl 1
                : 2107-2120
                Affiliations
                [2] Recife Pernambuco orgnameFaculdade Pernambucana de Saúde orgdiv1Laboratório de Farmacobotânica Brazil
                [1] Recife Pernambuco orgnameUniversidade Federal de Pernambuco orgdiv1Departamento de Ciências Farmacêuticas orgdiv2Laboratório de Farmacognosia Brazil
                Article
                S0001-37652018000502107
                10.1590/0001-3765201720160280
                28678961
                109381bd-46a9-4509-a6dd-1243571b2790

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 04 August 2016
                : 12 May 2016
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 72, Pages: 14
                Product

                SciELO Brazil


                histochemistry,phytochemistry,Asteraceae,Solidago chilensis,anatomy,arnica

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