Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial

Author(s): Hiddo J L Heerspink , Jai Radhakrishnan , Charles E Alpers , Jonathan Barratt , Stewart Bieler , Ulysses Diva , Jula Inrig , Radko Komers , Alex Mercer , Irene L Noronha , Michelle N Rheault , William Rote , Brad Rovin , Howard Trachtman , Hernán Trimarchi , Muh Geot Wong , Vlado Perkovic , Eric Alarmartine , Jonathan Barratt , Dong Wan Chae , Lucia Del Vecchio , Jurgen Floege , Shang-Jyh Hwang , Bojan Jelakovic , Bart Maes , Robert Malecki , Marius Miglinas , Fernando Eduardo Barbosa Nolasco , Manual Praga , Kannaiyan Rabindranath , Mai Rosenberg , Brad Rovin , Sydney Chi Wai Tang , Vladmir Tesar , Muh Geot Wong , Bhadran Bose , Muralikrishna Gangadharan , Stephen McDonald , Chen Peh , Sadia Jahan , Chii Yeap , Philip Clayton , Georgina Irish , Nikhil Thyagarajan , Peter Hollett , Rathika Krishnasamy , Robert Carroll , Shilpanjali Jesudason , Susan Crail , Toby Coates , Jane Waugh , Euan Noble , Kumaradevan Mahadevan , Victoria Campbell , Tania Salehi , Wai Lim , Neil Boudville , Aron Chakera , Doris Chan , Anoushka Krishnan , Yusuf Eqbal , Alastair Gillies , Eswari Vilayur , Thida Maung Maung Myint , Nicholas Gray , Jane Waugh , Euan Noble , Melissa Cheetham , Yusuf Eqbal , Peter Hollett , Rathika Krishnasamy , Kumaradevan Mahadevan , Victoria Campbell , Carol Pollock , Bruce Cooper , Amanda Mather , Sarah Roxburgh , Yvonne Shen , Stefanie Stangenberg , Amanda Siriwardana , Emma O'Lone , Susan Wan , Brendon Neuen , Jeffrey Tsun Kit Ha , Dana Kim , Lauren Heath , Arunima Jain , Elaine Phua , Yan Li , Martin Gallagher , Meg Jardine , Angus Ritchie , Mona Razavian , Celine Foote , Roger Wyndham , Shaundeep Sen , Zoltan Endre , Jonathan Erlich , Mangalee Fernando , Kenneth Yong , Grant Luxton , Sradha Kotwal , Simon Roger , Vidu Wijeratne , David Packham , Ian Fraser , Bert Vandewiele , Margo Laute , Wim Lemahieu , Sofie Jamar , Sara Ombelet , Gert Meeus , Marc Decupere , Olivier Schockaert , Peter Doubel , Liesbeth Viaene , Luc Radermacher , Catherine Masset , Martial Moonen , Eric Firre , Martina Milicevic , Xavier Warling , An Vanacker , Thomas Malfait , Ivan Durlen , Ivica Horvatic , Ana Savuk , Lana Gellineo , Sandra Karanovic , Zivka Dika , Djuro Plavljanic , Ivana Mikacic , Dubravka Trajbar Kentric , Dunja Barisic , Marija Stankovic , Karolina Majstorovic Barac , Ivan Kruljac , Drasko Pavlovic , Martin Drinkovic , Ingrid Prkacin , Jerko Barbic , Zvonimir Sitas , Dunja Vujcic , Ivan Rychlik , Anna Benesova , Klara Drinovska , Karolina Kratka , Dita Maixnerova , Madis Ilmoja , Kristin Unt , Kadri Lilienthal , Asta Auerbach , Liisi Leis , Julia Piel , Annika Adoberg , Kulli Kolvald , Kristi Veermae , Kadri Telling , Elviira Seppet , Jana Uhlinova , Philippe Zaoui , Pierre-Louis Carron , Ingrid Masson , Miriana Dinic , Damien Thibaudin , Christian Broyet , Nicolas Maillard , Hesham Mohey , Christophe Mariat , Guillaume Claisse , Eric Alamartine , Bertrand Dussol , Stephane Burtey , Noemie Chiche-Jourde , Jean-Emmanuel Serre , Guillaume Jeantet , Leila Chenine , Anne Blanchard , Stephane Roueff , Eric Thervet , David Fouassier , Alexandre Buffet , Marine Livrozet , Roxane Gaisset , Alexandre Karras , Anne-Elisabeth Heng , Cyril Garrouste , Carole Philipponnet , Clementine Nicolo , Alba Atenza , Camille Lanaret , Clarisse Greze , Valentin Mayet , Clement Dumond , Yahsou Delmas , Christian Combe , Claire Rigothier , Laure Burguet , Aurore Labat , Simon Mucha , Valérie de Précigout , Thomas Weinreich , Helmut Reichel , Diliana Draganova , Lothar Wolf , Bernd Hohenstein , Sven Heinrichs , Simone Kulka , Sebahat Sat , Lea Weiland , Thilo Krueger , Gunter Wolf , Christiane Kettner , Mandy Schlosser , Johann Konstantin Herfurth , Annegret Koch , Martin Busch , Stephan Christian Werth , Martin Nitschke , Figen Cakiroglu , Franziska Sarnow , Lisa Schulz , Stefan Weiner , Nikolaus Wirtz , Eric Koester , Marcus Moeller , Eleni Stamellou , Silja Sanden , Hans Schmidt-Guertler , Wanja Bernhardt , Margret Patecki , Georg Schlieper , Kevin Schulte , Annette Girardet , Ulrich Kunzendorf , Lorraine Pui Yuen Kwan , Maggie Ming Yee Mok , Gary Chi Wang Chan , Mingyao Ma , Davina Ngoi Wah Lie , Anthony Ting Pong Chan , Cheuk Chun Szeto , Kit Chung Jack Ng , Siu Fai Cheung , Tak Tai Andrew Yue , Ka Shun Samuel Fung , Hon Tang , Ka Fai Yim , Wai Ping Law , Yick Hei Wong , Chi Kwan Darwin Lam , Sze Ho Sunny Wong , Carmelita Marcantoni , Roberta Aliotta , Francesca Deodato , Gemma Patella , Nicolino Comi , Caterina Vita , Nazareno Carullo , Davide Bolignano , Michela Musolino , Matias Trillini , Norberto Perico , Giuseppe Remuzzi , Erica Daina , Luigi Biancone , Loredana Colla , Manuel Burdese , Chiara Cogno , Elena Boaglio , Isabella Abbasciano , Carlotta Federica Zizzi , Paolo Randone , Pietro Napodano , Anna Ricchiuto , Matthias Cassia , Simone Accarino , Mario Cozzolino , Rocco Baccaro , Stefano Costanzi , Federica Di Maio , Maria Arena , Federica Urciuolo , Sara Vigano , Andrea Cavalli , Monica Limardo , Monica Bordoli , Serena Ponti , Selena Longhi , Andrea Solazzo , Francesco Giaroni , Gabriele Donati , Massimo Torreggiani , Davide Catucci , Marco Colucci , Vittoria Esposito , Ciro Esposito , Loreto Gesualdo , Flavia Capaccio , Emma Diletta Stea , Carmen Sivo , Francesca Annese , Federica Papadia , Piergiorgio Messa , Mirco Belingheri , Patrizia Passerini , Silvia Malvica , Alvita Vickiene , Urte Zakauskiene , Egle Asakiene , Inga Arune Bumblyte' , Asta Stankuviene , Lina Santockiene , Ashik Hayat , Allister Williams , Peter Sizeland , Eddie Tan , Gerald Waters , Lai Wan Chan , Andrew Henderson , Angus Turnbull , Andrew McNally , Annie Reynolds , Helen Pilmore , Ian Dittmer , Paul Manley , Elizabeth Stallworthy , Tze Goh , David Semple , Michael Collins , Elizabeth Curry , Jafar Ahmed , Thu Nguyen , Agata Winiarska , Justyna Zbrzezniak , Tomasz Stompor , Magdalena Krajewska , Hanna Augustyniak-Bartosik , Dorota Zielinska , Anna Jander , Malgorzata Stanczyk , Marcin Tkaczyk , Przemyslaw Miarka , Dariusz Aksamit , Piotr Jaskowski , Wladyslaw Sulowicz , Dominik Cieniawski , Julita Gontarek-Kacprzak , Elzbieta Felicjanczuk , Norbert Kwella , Bogna Kwella , Ewa Satora , João Carlos Fernandes , Ana Marta Gomes , Marina Reis , Daniela Lopes , Catarina Almeida , Helena Sá , Ana Carolina Figueiredo , Clara Pardinhas , Edgar Almeida , Mario Raimundo , Ana Cortesão Costa , Luis Pedro Falcao Goncalves , Sara Fernandes , Sónia Silva , Catarina Teixeira , Adriana Fernandes , Fernando Nolasco , Patricia Alves , Mario Gois , Nuno Fonseca , Ana Messias , Maria Menezes , Filipa Cardoso , Helena Sousa , Joana Marques , Rui Barata , Jose Antonio Lopes , Sofia Jorge , Joana Gameiro , Jose Nuno de Almeida Agapito Fonseca , Sara Goncalves , Ana Farinha , Patricia Valerio Santos , Ana Natario , Jose Carlos de Jesus Barreto , Catarina Abrantes , Elsa Sofia Quadrado Soares , Joana de Sousa Soares Felgueiras , Liliana Cunha , Lucia Parreira , Teresa Furtado , Alvaro Vaz , Kook-Hwan Oh , Hajeong Lee , Se Joong Kim , Jong Cheol Jeong , Yeong Hoon Kim , Yunmi Kim , Hyeong Cheon Park , Hoon Young Choi , Hyung Wook Kim , Moon Hyoung Lee , Songuk Yoon , Kyu-Beck Lee , YoungYoul Hyun , Tae-Hyun Yoo , Seung Hyeok Han , Jung Tak Park , Sunggyun Kim , Young Rim Song , Jwa-Kyung Kim , Hyung-seok Lee , Narae Joo , JungEun Lee , Hye Ryoun Jang , Junseok Jeon , Wookyung Chung , HyunHee Lee , Jae Hyun Chang , Ka Yeong Chun , Ji Yong Jung , Han Ro , Aejin Kim , Sang-Kyung Jo , Jihyun Yang , Myung-Gyu Kim , SeWon Oh , Caridad Martinez Villanueva , Ana Vilar Gimeno , Gustavo Andres Useche Bonilla , Esther Tamarit , Antonio Galan Serrano , Eduardo Verde Moreno , Jose Luño Fernandez , Maria Angeles Goicoechea Diezhandino , Ursula Verdalles Guzman , Ana Perez de Jose , Alberto Ortiz Arduan , María Vanessa Pérez Gómez , Catalina Martín Cleary , Raul Fernandez Prado , Elena Goma , Jose Ballarin , Montserrat Diaz Encarnacion , Iara Da Silva Santos , Helena Marco Rusinol , Monica Furlano , Carlos Arias , Clara Barrios , Eva Rodriguez Garcia , Adriana Sierra Ochoa , Belen Vizcaino Castillo , Jonay Pantoja Perez , Mercedes Gonzalez Moya , Mari Sargsyan , Emma Calatayud Aristoy , Ana Avila Bernabeu , Leticia Perez Lluna , Tamara Malek Marin , Maria Antonia Munar Vila , Ivon Maritza Bobadilla Rico , Natalia Allende Burgos , Eduardo Gutierrez Martinez , Elena Gutierrez Solis , Angel Sevillano , Evangelina Merida Herrero , Josep Miquel Blasco Pelicano , Lida Maria Rodas Marin , Luis F Quintana , Maria Antonieta Azancot Rivero , Natalia Ramos Terrades , Clara Garcia Carro , Irene Agraz Pamplona , Mercedes Salgueira Lazo , Francisco de la Prada Alvarez , Fabiola Alonso Garcia , Wenceslao Adrian Aguilera Morales , Salia Virxinia Pol Heres , Angel Forcen , Eduardo Parra Moncasi , Cristina Medrano Villarroya , Alejandro Soria Villen , Olga Gracia Garcia , Mercedes Velo Plaza , Maria Dolores Sánchez de la Nieta , Marta Calvo Arevalo , Antolina Moreno , Secundino Cigarran Guldris , Manuel Pereira de Vicente , Maria Antonia Munar Vila , Ivon Maritza Bobadilla Rico , Natalia Allende Burgos , Bang-Gee Hsu , Chih-Hsien Wang , Cheng-Hsu Chen , Tung-Min Yu , Ming-Ju Wu , Shang-Feng Tsai , Chia-Tien Hsu , Hsien-Fu Chiu , Kang-Ju Chou , Hua-Chang Fang , Po-Tsang Lee , Hsin-Yu Chen , Chien-Liang Chen , Chien-Wei Huang , Shih-Hsiang Ou , Tzung-Yo Ho , Chih-Yang Hsu , Ming-Shan Chang , Yen-Ling Chiu , Yu-Sen Peng , Kai-Hsiang Shu , Szu-Yu Pan , Shih-Ping Hsu , Ju-Yeh Yang , Mei-Fen Pai , Po-Yu Tseng , Hon-Yen Wu , Wan-Chuan Tsai , Kuei-Ting Tung , Hung-Yuan Chen , Hung-Chun Chen , Mei-Chuan Kuo , Daw-Yang Hwang , Yi-Wen Chiu , Chi-Chih Hung , Hung-Tien Kuo , Jer-Chia Tsai , Kieran McCafferty , Suzanne Forbes , Indranil Dasgupta , Mark Thomas , Amar Mahdi , Bamidele Ajayi , Paramit Chowdhury , Theodoros Kasimatis , Dimitrios Moutzouris , Caroline Dudreuilh , Rishi Pruthi , Nick Mansfield , Gabriel Doctor , Sapna Shah , Sui Kon , Priscilla Smith , Patrick Hamilton , Durga Kanigicherla , Omar Sherin Ibrahim Ragy , Bassam Alchi , Oliver Flossmann , Farid Ghalli , Sarah Lawman , Smeeta Sinha , Constantina Chrysochou , Chukwuma Chukwu , Aine Maire De Bhailis , Saif Al Chalabi , Amy Hudson , Arun Gopu , Olivia Wickens , Joshua Storrar , Mona Wahba , Nathan Lorde , Mohammad Rony , Sian Griffin , Farah Latif , Mohammad Ali , Louise DaSilva , Jonathan Ayling-Smith , Eamon Mahdi , Lisa Willcocks , Rachel Jones , Chee Kay Cheung , Haresh Selvaskandan , Dan Pugh , Matthew Sayer , Neeraj Dhaun , Fiona Chapman , Patrick Mark , Colin Geddes , Emily McQuarrie , Rajan Patel , Laurence Solomon , Arvind Ponnusamy , Adam Morris , Pedro Okoh , Lauren Floyd , Ajay Dhaygude , Janson Leung , Christopher Goldsmith , Bhavna Pandya , Didem Tez , Ashraf Mikhail , Karen Brown , Thomas Bucknall , Mark Lambie , Roderick Comunale , Donald Brandon , Stacy Martinez , Amanda Hall , Amy Henderson , Aaron Fearday , Nicole Douthit , Brian Snow , Arnold Silva , Cathylee Sly , Christopher Keller , Robert Davidson , Jerry Meng , Robert Haws , Siddhartha Kattamanchi , Javad Mojarrab , Unnikrishnan Pillai , Richard Lafayette , Michelle O'Shaughnessy , Fahameedah Kamal , Kshama Mehta , Bruce Baker , Mario Ruiz , Praveena Jyothinagaram , Usha Peri , William Paxton , James Tumlin , Kerri McGreal , Ellen McCarthy , Cassandra Kimber , Archana Gautam , Kassem Khalil , Viet Nguyen , Viet Nguyen , Raffi Minasian , Dariush Arfaania , Sam Daneshvari , Michel Zakari , Artashes Patrikyan , Rouzbeh Afsari , Christine Ayvazyan , Faisal Fakih , Mark Lagatta , Faisal Fakih , Alfred Rodriguez , Jorge Enrique Monroy Avella , Ramachandra Patak , Jigar Kadakia , Jai Radhakrishnan , Gerald Appel , Wooin Ahn , Bradley Nelson , Allyson Medina , Syeda Ahmad , Yonatan Peleg , Nisha Clement , Ian Chiu , Elizabeth Hendren , Andrew Bomback , Pietro Canetta , Bruce Spinowitz , Chaim Charytan , Nishita Parikh , Sheng Kuo , Ritesh Raichoudhury , Mirela Dobre , Lavinia Negrea , Aparna Padiyar , Arksarapuk Jittirat , Nishigandha Pradhan , Ranjit Dhelaria , Saravanan Balamuthusamy , Machaiah Madhrira , Thomas Powell , Howard Lifland , Asha Bailey , Sarah Ashley Ford Sightler , Meera Patel Suthar , Heather Green , Samir Parikh , Isabelle Ayoub , Salem Almaani , Gabriel Contreras , Alessia Fornoni , Yelena Drexler , Abdallah Geara , Brittany Sheridan , Gaia Coppock , Jonathan Hogan , Carlos Gonzalez , Shamik Bhadra , Pradip Chowdhury , Kay Kyaw , May Tan , Lathika Raakesh , Elder Mendoza , Veronica Viramontes , Asghar Chaudhry , Juan Carbonell , Rajdeep Gadh , Victor Fernandez , Mohamad Kassem , Radu Jacob , Karen Wilder , Britt Newsome , Kathryn Klamm , Irina Suyumova , Laura Ann Kooienga , Catherine Janko , Dana Rizk , Bruce Julian , Dawn Caster , Erika Perez , Gunjan Garg , Nayan Gowda , Suneel Udani , Sreedhar Mandayam , Biruh Workeneh , Roderick Comunale , Donald Brandon , Unnikrishnan Pillai , Ali Assefi , Barbara Greco , Michael Germain , Jusmin Patel , Sarah Quinn , James Sullivan , Jeffrey Glaze , Phillip Madonia , Kellyn McMahon , Harold Giles , Sharon Adler , Tiane Dai

Publication date Created: April 2023

Publication date (Print): April 2023

Journal: The Lancet

Publisher: Elsevier BV