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Subsets of very low risk Wilms tumor show distinctive gene expression, histologic, and clinical features.
Simone T Sredni
1 ,
Samantha Gadd ,
Chiang-Ching Huang ,
Norman Breslow ,
Paul Grundy ,
Daniel M Green ,
Jeffrey S Dome ,
Robert C Shamberger ,
J Bruce Beckwith ,
Elizabeth J Perlman
Nov 15 2009
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Abstract
Recent studies suggest that children <24 months with stage I favorable histology Wilms tumors <550 g [very low risk Wilms tumors (VLRWT)] have an excellent prognosis when treated with nephrectomy only, without adjuvant chemotherapy. The identification of risk categories within VLRWT may enable refinement of their definition and optimization of their therapy.