For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
106
views
51
references
 Top references
cited by
92
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      729
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Mucoadhesive drug delivery system: An overview

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Thus, mucoadhesive dosage forms are advantageous in increasing the drug plasma concentrations and also therapeutic activity. In this regard, this review covers the areas of mechanisms and theories of mucoadhesion, factors influencing the mucoadhesive devices and also various mucoadhesive dosage forms.

          Related collections

          Most cited references51

          • Record: found
          • Abstract: found
          • Article: not found

          Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis.

          G Ikinci, S Senel, H Akıncıbay … (2002)
          Local delivery systems of antimicrobial agents for treatment of the periodontal diseases received considerable attention during the past decade due to the disadvantages of the systemic administration. An ideal formulation should exhibit ease of delivery, a good retention at the application site, and a controlled release of the drug. The application of bioadhesive gels provides a long stay in the oral cavity, adequate drug penetration, high efficacy and acceptability. In dentistry and oral medicine, various applications of chitosan, which is a bioadhesive polymer have been proposed due to its favorable properties such as biocompatibility and biodegradability. The aim of this study was to determine the antimicrobial activity of chitosan formulations either in gel or film form against a periodontal pathogen, Porphyromonas gingivalis. The viscosity, bioadhesive properties and antimicrobial activity of chitosans at different molecular weight and deacetylation degree were evaluated in the absence or presence of chlorhexidine gluconate (Chx), incorporated into the formulations at 0.1 and 0.2% concentrations. The flow property of the gels were found to be suitable for topical application on the oral mucosa and to syringe into the periodontal pocket. Bioadhesion of the gels and films examined ex-vivo using fresh porcine buccal mucosa showed that both the film and gel formulations exert bioadhesive properties and was not affected by incorporation of Chx. Chitosan is shown to have an antimicrobial activity against P. gingivalis and this was higher with high molecular weight chitosan. The combination of chitosan with Chx showed a higher activity when compared to that of Chx alone, which would provide Chx application at lower concentrations thus avoiding its unwanted side effects. Chitosan films and gels seem to be promising delivery systems for local therapy of periodontal diseases with its bioadhesive property and antimicrobial activity.
          Article 0 comments Cited 41 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Buccal mucosa as a route for systemic drug delivery: a review.

            A H Shojaei (2015)
            Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic drug delivery. The mucosa has a rich blood supply and it is relatively permeable. It is the objective of this article to review buccal drug delivery by discussing the structure and environment of the oral mucosa and the experimental methods used in assessing buccal drug permeation/absorption. Buccal dosage forms will also be reviewed with an emphasis on bioadhesive polymeric based delivery systems
            Article 0 comments Cited 40 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Molecular aspects of muco- and bioadhesion: tethered structures and site-specific surfaces.

              W Leobandung, N A Peppas, Catherine A Foss … (2000)
              Mucoadhesive controlled-release devices can improve the effectiveness of a drug by maintaining the drug concentration between the effective and toxic levels, inhibiting the dilution of the drug in the body fluids, and allowing targeting and localization of a drug at a specific site. Acrylic-based hydrogels have been used extensively as mucoadhesive systems. They are well suited for bioadhesion due to their flexibility and nonabrasive characteristics in the partially swollen state, which reduce damage-causing attrition to the tissues in contact. Crosslinked polymeric devices may be rendered adhesive to the mucosa. For example, adhesive capabilities of these hydrogels can be improved by tethering of long flexible chains to their surfaces. Tethering of long poly(ethylene glycol) (PEG) chains on poly(acrylic acid) hydrogels and their copolymers can be achieved by grafting reactions, or by copolymerization in the presence of several PEG-containing acrylates. The ensuing hydrogels exhibit mucoadhesive properties due to enhanced anchoring of the chains with the mucosa. Theoretical calculations can lead to optimization of the tethered structure. Experimental results indicate that the chain interpenetration is a strong function of the PEG molecular weight, the polymer swelling ratio and the mucosa composition.
              Article 0 comments Cited 28 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Adv Pharm Technol Res
                Journal ID (publisher-id): JAPTR
                Title: Journal of Advanced Pharmaceutical Technology & Research
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 2231-4040
                ISSN (Electronic): 0976-2094
                Publication date (Print): Oct-Dec 2010
                Volume: 1
                Issue: 4
                Pages: 381-387
                Affiliations
                [1]Department of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh - 508 001, India
                [1 ]Faculty of Technology, Osmania University, Hyderabad, Andhra Pradesh – 500 013, India
                Author notes
                Address for correspondence: Dr. Bindu Madhavi B., Department of Pharmaceutics, Nalanda College of Pharmacy, Cherlapalli, Nalgonda, Andhra Pradesh - 508 001, India. E-mail: bindu_ramu12@ 123456yahoo.com
                Article
                Publisher ID: JAPTR-1-381
                DOI: 10.4103/0110-5558.76436
                PMC ID: 3255397
                PubMed ID: 22247877
                SO-VID: 0e225c4d-ba7a-454e-832b-ccb70974a931
                Copyright © Copyright: © Journal of Advanced Pharmaceutical Technology & Research
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Subject: Review Article

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: mucoadhesive dosage forms,mucoadhesion,theories
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: mucoadhesive dosage forms, mucoadhesion, theories

                Comments

                Comment on this article

                scite_

                Similar content729

                See all similar

                Cited by92

                See all cited by

                Most referenced authors259

                See all reference authors