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      Central cortical cleanup and zonular deficiency

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          Abstract

          Background

          Complete removal of the cortex has been advocated to prevent posterior capsular opacification but carries the risk of zonular dehiscence, hence there is a need for a safe maximal cortical cleanup technique in eyes with severe diffuse zonulopathy in subjects above age 90.

          Methods

          We used bimanual central cortical cleaning by elevating central fibers and aspirating them toward the periphery. Peripheral cortical fibers were removed passively only when they became loose due to copious irrigation. A one-piece foldable implant was inserted without a capsular tension ring. Postoperative corticosteroid drops were used.

          Results

          This technique was safely performed in a dozen eyes with severe pseudo-exfoliation or brunescent cataract with weak zonules. Posterior capsular rupture, iritis, vitreous loss, and lens subluxation were not observed. Moderate capsular phimosis occurred but with maintained central vision.

          Conclusion

          The dogma of “complete cortical cleanup” in severe zonulopathy needs to be revisited in favor of a clear visual axis with maximal preservation of the damaged zonules. This technique is ideal in patients above age 90 where posterior capsular opacification and late dislocation of intraocular lens–capsule bag complex are unlikely to occur until several years postoperatively.

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          Most cited references13

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          Posterior capsule opacification.

          A complication of extracapsular cataract extraction with or without posterior chamber intraocular lens (PC-IOL) implantation is posterior capsule opacification. This condition is usually secondary to a proliferation and migration of residual lens epithelial cells. Opacification may be reduced by atraumatic surgery and thorough cortical clean-up. Clinical, pathological and experimental studies have shown that use of hydrodissection, the continuous curvilinear capsulorhexis and specific IOL designs may help reduce the incidence of this complication. Capsular-fixated, one-piece all-polymethylmethacrylate PC-IOLs with a C-shaped loop configuration and a posterior convexity of the optic are effective. Polymethylmethacrylate loops that retain "memory" create a symmetric, radial stretch on the posterior capsule after in-the-bag placement, leading to a more complete contact between the posterior surface of the IOL optic and the taut capsule. This may help form a barrier against central migration of epithelial cells into the visual axis. Various pharmacological and immunological methods are being investigated but conclusive data on these modalities are not yet available.
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            Possible predisposing factors for in-the-bag and out-of-the-bag intraocular lens dislocation and outcomes of intraocular lens exchange surgery.

            To examine the possible predisposing factors for intraocular lens (IOL) dislocation within the capsular bag (in-the-bag dislocation) and IOL dislocation outside of the capsule (out-of-the-bag dislocation) and to study surgical outcomes of explantation of dislocated IOLs and scleral suturing of posterior chamber IOLs. Retrospective interventional case series. Thirty-eight eyes of 38 patients who developed in-the-bag IOL dislocation and 24 eyes of 24 patients who experienced out-of-the-bag dislocation. Medical records of 62 consecutive patients who underwent IOL exchange surgery for dislocation between 1999 and 2005 were reviewed. Possible predisposing factors and the other characteristics of in-the-bag and out-of-the-bag IOL dislocations; outcomes of IOL exchange surgery, including visual acuity (VA) and refractive status before and at 12 months after surgery; and serious postoperative complications. Possible major predisposing factors for in-the-bag IOL dislocation were pseudoexfoliation (17/38 [44.7%]), retinitis pigmentosa (4/38 [10.5%]), the status after vitrectomy (2/38 [5.3%]), trauma (2/38 [5.3%]), and a long axis (2/38 [5.3%]), whereas those for out-of-the-bag dislocation were secondary IOL implantation (11/24 [45.8%]), surgical complications (3/24 [12.5%]), mature cataract (3/24 [12.5%]), and pseudoexfoliation (2/24 [8.3%]). The interval between IOL implantation and exchange surgery was significantly shorter for the in-the-bag dislocation group than for the out-of-the-bag dislocation group (P = 0.0006). Mean uncorrected VA improved significantly after IOL exchange (P = 0.0080), and corrected VA also tended to improve, although the improvement was not significant (P = 0.0704). Mean absolute value of spherical power decreased significantly after surgery (P = 0.0008), whereas refractive astigmatism showed a significant increase (P = 0.0003). The primary serious complications after surgery were a marked rise in intraocular pressure (12/62, 19.4%), retinal detachment (4/62, 6.5%), and redislocation (2/62, 3.2%). Possible major predisposing factors for in-the-bag IOL dislocation are pseudoexfoliation, retinitis pigmentosa, the status after vitrectomy, and trauma, whereas those for out-of-the-bag dislocation are secondary implantation, surgical complications, and mature cataract. After IOL exchange surgery, corrected VA does not improve markedly. Because the incidence of postoperative complications after IOL exchange with scleral suturing is high, the use of other surgical techniques should be considered.
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              Development, composition, and structural arrangements of the ciliary zonule of the mouse.

              Here, we examined the development, composition, and structural organization of the ciliary zonule of the mouse. Fibrillin 1, a large glycoprotein enriched in force-bearing tissues, is a prominent constituent of the mouse zonule. In humans, mutations in the gene for fibrillin 1 (FBN1) underlie Marfan syndrome (MS), a disorder characterized by lens dislocation and other ocular symptoms. Fibrillin expression was analyzed by in situ hybridization. The organization of the zonule was visualized using antibodies to Fbn1, Fbn2, and microfibril-associated glycoprotein-1 (Magp1) in conjunction with 5-ethynyl-2'-deoxyuridine (EdU), an S-phase marker. Microfibrils, enriched in Fbn2 and Magp1, were prominent components of the temporary vascular tunic of the embryonic lens. Fbn2 expression by nonpigmented ciliary epithelial cells diminished postnatally and there was a concomitant increase in Fbn1 expression, especially in cells located in valleys between the ciliary folds. Zonular fibers projected from the posterior pars plicata to the lens in anterior, equatorial, and posterior groupings. The attachment point of the posterior zonular fibers consisted of a dense meshwork of radially oriented microfibrils that we termed the fibrillar girdle. The fibrillar girdle was located directly above the transition zone, a region of the lens epithelium in which cells commit to terminal differentiation. The development and arrangement of the murine ciliary zonule are similar to those of humans, and consequently the mouse eye may be a useful model in which to study ocular complications of MS.
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                Author and article information

                Journal
                Clin Ophthalmol
                Clin Ophthalmol
                Clinical Ophthalmology
                Clinical Ophthalmology (Auckland, N.Z.)
                Dove Medical Press
                1177-5467
                1177-5483
                2016
                04 October 2016
                : 10
                : 1919-1923
                Affiliations
                [1 ]Department of Ophthalmology, American University of Beirut, Beirut, Lebanon
                [2 ]Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon
                [3 ]Department of Ophthalmology, University of Toronto, Toronto, ON, Canada
                Author notes
                Correspondence: Iqbal Ike K Ahmed, Department of Ophthalmology, University of Toronto, 27 King’s College Circle, Toronto, ON M5S, Canada, Email ikeahmed@ 123456mac.com
                Article
                opth-10-1919
                10.2147/OPTH.S116314
                5063496
                0de38fd7-8fed-4fa2-937b-0956bebf263f
                © 2016 Mansour et al. This work is published and licensed by Dove Medical Press Limited

                The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Expert Opinion

                Ophthalmology & Optometry
                brunescent cataract,cortex aspiration,phacoemulsification,pseudo-exfoliation,weak zonules

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