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How nucleotide excision repair protects against cancer.

Publication date: 2001-09-30

Keywords: Animals, DNA Damage, DNA Repair, genetics, Disease Models, Animal, Humans, Mutation, Neoplasms, etiology, prevention & control, Transcription, Genetic, Xeroderma Pigmentosum

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Abstract

Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type--nucleotide excision repair (NER)--specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

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PubMed ID:: 11900249

DOI:: 10.1038/35094000

ScienceOpen disciplines: Chemistry

Keywords: Animals,DNA Damage,DNA Repair,genetics,Disease Models, Animal,Humans,Mutation,Neoplasms,etiology,prevention & control,Transcription, Genetic,Xeroderma Pigmentosum

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ScienceOpen disciplines: Chemistry

Keywords: Animals, DNA Damage, DNA Repair, genetics, Disease Models, Animal, Humans, Mutation, Neoplasms, etiology, prevention & control, Transcription, Genetic, Xeroderma Pigmentosum

How nucleotide excision repair protects against cancer.

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Photoluminescent Nanomaterials

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