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      Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin

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      Author(s): a , b , b , , a ,
      Publication date (Electronic):
      Journal: Genome Announcements
      Publisher: American Society for Microbiology

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          Abstract

          Currently, corticosteroids are the most potent anti-inflammatory drugs on the market. Here, we announce the draft genome sequence of the marine-derived Streptomyces sp. strain CNQ431, which produces cytokine inhibitors, termed splenocins, which display potent suppression of cytokine production at a comparable level to that of corticosteroids. The genome is approximately 498,750 bp with 72.03% G+C content.

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          Antigen presentation to naive CD4 T cells in the lymph node.

          Richard Jenkins, Andrea A. Itano (2003)
          Although the presentation of peptide-major histocompatibility complex class II (pMHC class II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process in vivo is limited. Unlike the in vitro situation, antigen presentation in vivo takes place within a complex microenvironment in which the movements of antigens, antigen-presenting cells (APCs) and T cells are governed by anatomic constraints. Here we review developments in the areas of lymph node architecture, APC subsets and T cell activation that have shed light on how antigen presentation occurs in the lymph nodes.
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            Insights into naturally minimised Streptomyces albus J1074 genome

            Nestor Zaburannyi, Mariia Rabyk, Bohdan Ostash … (2014)
            Background The Streptomyces albus J1074 strain is one of the most widely used chassis for the heterologous production of bioactive natural products. The fast growth and an efficient genetic system make this strain an attractive model for expressing cryptic biosynthetic pathways to aid drug discovery. Results To improve its capabilities for the heterologous expression of biosynthetic gene clusters, the complete genomic sequence of S. albus J1074 was obtained. With a size of 6,841,649 bp, coding for 5,832 genes, its genome is the smallest within the genus streptomycetes. Genome analysis revealed a strong tendency to reduce the number of genetic duplicates. The whole transcriptomes were sequenced at different time points to identify the early metabolic switch from the exponential to the stationary phase in S. albus J1074. Conclusions S. albus J1074 carries the smallest genome among the completely sequenced species of the genus Streptomyces. The detailed genome and transcriptome analysis discloses its capability to serve as a premium host for the heterologous production of natural products. Moreover, the genome revealed 22 additional putative secondary metabolite gene clusters that reinforce the strain’s potential for natural product synthesis.
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              Th2 cytokines and asthma — The role of interleukin-5 in allergic eosinophilic disease

              Scott Greenfeder, Shelby Umland, Francis Cuss … (2001)
              Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Genome Announc
                Journal ID (iso-abbrev): Genome Announc
                Journal ID (hwp): ga
                Journal ID (pmc): ga
                Journal ID (publisher-id): GA
                Title: Genome Announcements
                Publisher: American Society for Microbiology (1752 N St., N.W., Washington, DC )
                ISSN (Electronic): 2169-8287
                Publication date (Electronic): 22 January 2015
                Publication date Collection: Jan-Feb 2015
                Volume: 3
                Issue: 1
                Electronic Location Identifier: e01383-14
                Affiliations
                [a ]Department of Preclinical Medicine, Harbin Medical University, Harbin, China
                [b ]School of Pharmaceutical Science, Wuhan University, Wuhan, China
                Author notes
                Address correspondence to Xudong Qu, quxd@ 123456whu.edu.cn , or Xu Gao, gaoxu6712@ 123456163.com .
                Article
                Publisher ID: genomeA01383-14
                DOI: 10.1128/genomeA.01383-14
                PMC ID: 4319611
                PubMed ID: 25614558
                SO-VID: 0d533f0a-3b05-4210-8ebc-fe4b72cae89b
                Copyright © Copyright © 2015 Yu et al.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.

                History
                Date received : 22 November 2014
                Date accepted : 9 December 2014
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 12, Pages: 2, Words: 1062
                Categories
                Subject: Prokaryotes
                Custom metadata
                cover-date January/February 2015
                access-type free

                ScienceOpen disciplines: Genetics
                Data availability:
                ScienceOpen disciplines: Genetics

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