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      A multi-frame network model for predicting seizure based on sEEG and iEEG data

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          Abstract

          Introduction

          Analysis and prediction of seizures by processing the EEG signals could assist doctors in accurate diagnosis and improve the quality of the patient's life with epilepsy. Nowadays, seizure prediction models based on deep learning have become one of the most popular topics in seizure studies, and many models have been presented. However, the prediction results are strongly related to the various complicated pre-processing strategies of models, and cannot be directly applied to raw data in real-time applications. Moreover, due to the inherent deficiencies in single-frame models and the non-stationary nature of EEG signals, the generalization ability of the existing model frameworks is generally poor.

          Methods

          Therefore, we proposed an end-to-end seizure prediction model in this paper, where we designed a multi-frame network for automatic feature extraction and classification. Instance and sequence-based frames are proposed in our approach, which can help us simultaneously extract features of different modes for further classification. Moreover, complicated pre-processing steps are not included in our model, and the novel frames can be directly applied to the raw data. It should be noted that the approaches proposed in the paper can be easily used as the general model which has been validated and compared with existing model frames.

          Results

          The experimental results showed that the multi-frame network proposed in this paper was superior to the existing model frame in accuracy, sensitivity, specificity, F1-score, and AUC in the classification performance of EEG signals.

          Discussion

          Our results provided a new research idea for this field. Researchers can further integrate the idea of the multi-frame network into the state-of-the-art single-frame seizure prediction models and then achieve better results.

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          Most cited references46

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          Long Short-Term Memory

          Learning to store information over extended time intervals by recurrent backpropagation takes a very long time, mostly because of insufficient, decaying error backflow. We briefly review Hochreiter's (1991) analysis of this problem, then address it by introducing a novel, efficient, gradient-based method called long short-term memory (LSTM). Truncating the gradient where this does not do harm, LSTM can learn to bridge minimal time lags in excess of 1000 discrete-time steps by enforcing constant error flow through constant error carousels within special units. Multiplicative gate units learn to open and close access to the constant error flow. LSTM is local in space and time; its computational complexity per time step and weight is O(1). Our experiments with artificial data involve local, distributed, real-valued, and noisy pattern representations. In comparisons with real-time recurrent learning, back propagation through time, recurrent cascade correlation, Elman nets, and neural sequence chunking, LSTM leads to many more successful runs, and learns much faster. LSTM also solves complex, artificial long-time-lag tasks that have never been solved by previous recurrent network algorithms.
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            ImageNet classification with deep convolutional neural networks

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              Gradient-based learning applied to document recognition

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                Author and article information

                Contributors
                Journal
                Front Comput Neurosci
                Front Comput Neurosci
                Front. Comput. Neurosci.
                Frontiers in Computational Neuroscience
                Frontiers Media S.A.
                1662-5188
                14 November 2022
                2022
                : 16
                : 1059565
                Affiliations
                [1] 1Academy of Medical Engineering and Translational Medicine, Tianjin University , Tianjin, China
                [2] 2School of Mathematics, Tianjin University , Tianjin, China
                [3] 3Tianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin University , Tianjin, China
                [4] 4Laboratory of Neural Engineering and Rehabilitation, Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University , Tianjin, China
                [5] 5Tianjin International Joint Research Center for Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University , Tianjin, China
                Author notes

                Edited by: Gaurav Dhiman, Government Bikram College of Commerce Patiala, India

                Reviewed by: Mohammed Ambusaidi, UTAS, Oman; Hao Liu, Nanjing University of Aeronautics and Astronautics, China; Yujin Wang, Ningbo University of Technology, China

                *Correspondence: Xin Zhang xin_zhang_bme@ 123456163.com

                †These authors have contributed equally to this work and share first authorship

                Article
                10.3389/fncom.2022.1059565
                9701721
                36452007
                0ba6389f-10ee-4639-9b71-16e9d47e26af
                Copyright © 2022 Lu, Zhang, Wu, Ma, Zhang and Ni.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 01 October 2022
                : 20 October 2022
                Page count
                Figures: 12, Tables: 6, Equations: 7, References: 47, Pages: 15, Words: 7983
                Funding
                Funded by: Natural Science Foundation of Tianjin City, doi 10.13039/501100006606;
                Categories
                Neuroscience
                Original Research

                Neurosciences
                deep learning,eeg,multi-frame network,seizure prediction,feature extraction,pre-ictal
                Neurosciences
                deep learning, eeg, multi-frame network, seizure prediction, feature extraction, pre-ictal

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