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      Epidural anesthesia for pilonidal sinus surgery: ropivacaine versus levobupivacaine

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          Abstract

          Background

          Epidural anesthesia is one of the best options for lower abdominal and lower limb surgery. However, there have been insufficient reports regarding the use of epidural anesthesia for pilonidal sinus surgery. The present study was performed to compare the clinical profiles of epidural block performed with 0.75% levobupivacaine and 0.75% ropivacaine in this procedure.

          Methods

          Thirty patients undergoing pilonidal sinus surgery were randomly allocated into two groups: one group received levobupivacaine and the other received ropivacaine at 0.75% in a volume of 10 ml. Arterial blood pressure, heart rate, oxygen saturation, the onset time of analgesia and duration of block, highest sensory block level, perioperative and postoperative side effects, and patients' and surgeons' satisfaction were recorded.

          Results

          Hemodynamic stability was maintained in both groups throughout surgery. The onset time of analgesia (the time from epidural injection of local anesthetic to reach L 2 sensorial block) was 6.26 ± 3.49 min in the levobupivacaine group and 4.06 ± 1.75 min in the ropivacaine group (P = 0.116). The duration of sensorial block (time for regression of sensory block to L 2) was 297.73 ± 70.94 min in group L and 332.40 ± 102.22 min in group R (P = 0.110). Motor block was not seen in any of the patients in the study groups. Patients' and surgeons' satisfaction with the anesthetic technique were mostly excellent in both groups.

          Conclusions

          In patients undergoing pilonidal sinus surgery, both levobupivacaine and ropivacaine produce rapid and excellent epidural block without leading to motor block or significant side effects. Although not statistically significant, the onset time of anesthesia was shorter and the duration of effect was longer with ropivacaine than with levobupivacaine in this study.

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          Most cited references25

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          Ropivacaine: A review of its pharmacology and clinical use

          Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure enantiomer. It produces effects similar to other local anaesthetics via reversible inhibition of sodium ion influx in nerve fibres. Ropivacaine is less lipophilic than bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity. The drug displays linear and dose proportional pharmacokinetics (up to 80 mg administered intravenously). It is metabolised extensively in the liver and excreted in urine. The present article details the clinical applications of ropivacaine and its current place as a local anaesthetic in the group.
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            ASRA practice advisory on local anesthetic systemic toxicity.

            The American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity assimilates and summarizes current knowledge regarding the prevention, diagnosis, and treatment of this potentially fatal complication. It offers evidence-based and/or expert opinion-based recommendations for all physicians and advanced practitioners who routinely administer local anesthetics in potentially toxic doses. The advisory does not address issues related to local anesthetic-related neurotoxicity, allergy, or methemoglobinemia. Recommendations are based primarily on animal and human experimental trials, case series, and case reports. When objective evidence is lacking or incomplete, recommendations are supplemented by expert opinion from the Practice Advisory Panel plus input from other experts, medical specialty groups, and open forum. Specific recommendations are offered for the prevention, diagnosis, and treatment of local anesthetic systemic toxicity.
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              Consensus guidelines for managing postoperative nausea and vomiting.

              We present evidence-based guidelines developed by an international panel of experts for the management of postoperative nausea and vomiting.
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                Author and article information

                Journal
                Korean J Anesthesiol
                Korean J Anesthesiol
                KJAE
                Korean Journal of Anesthesiology
                The Korean Society of Anesthesiologists
                2005-6419
                2005-7563
                April 2015
                30 March 2015
                : 68
                : 2
                : 141-147
                Affiliations
                Department of Anesthesiology and Reanimation, Göztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
                Author notes
                Corresponding author: Zeynep Nur Orhon, M.D. Department of Anesthesiology and Reanimation, Göztepe Training and Research Hospital, Istanbul Medeniyet University, H©¥z©¥rbey Cad. Cüre Apt. 221/4, Göztepe/Istanbul, 34730, Turkey. Tel: 902165665740, Fax: 902165709081, zeynepnurorhon@ 123456gmail.com
                Article
                10.4097/kjae.2015.68.2.141
                4384401
                0b67bbcd-0533-4566-93ff-ca7563523e3e
                Copyright © the Korean Society of Anesthesiologists, 2015

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 04 April 2014
                : 15 August 2014
                : 15 August 2014
                Categories
                Clinical Research Article

                Anesthesiology & Pain management
                epidural anesthesia,levobupivacaine,pilonidal sinus surgery,ropivacaine

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