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      CD4−/CD8− double-negative tumor-infiltrating lymphocytes expanded from solid tumor tissue suppress the proliferation of tumor cells in an MHC-independent way

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          Abstract

          Tumor-infiltrating lymphocytes (TILs) have shown remarkable clinical responses in some patients with advanced solid tumors. As a rare subset of TILs, CD4-/CD8- double-negative T cells (DNTs) were poorly known. This study aims to investigate the characteristics and function of CD3+CD4-CD8- TILs (double-negative TIL, DN-TILs) derived from solid tumor.

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          Comprehensive Integration of Single-Cell Data

          Tim Stuart, Andrew Butler, Paul Hoffman … (2019)
          Single-cell transcriptomics has transformed our ability to characterize cell states, but deep biological understanding requires more than a taxonomic listing of clusters. As new methods arise to measure distinct cellular modalities, a key analytical challenge is to integrate these datasets to better understand cellular identity and function. Here, we develop a strategy to "anchor" diverse datasets together, enabling us to integrate single-cell measurements not only across scRNA-seq technologies, but also across different modalities. After demonstrating improvement over existing methods for integrating scRNA-seq data, we anchor scRNA-seq experiments with scATAC-seq to explore chromatin differences in closely related interneuron subsets and project protein expression measurements onto a bone marrow atlas to characterize lymphocyte populations. Lastly, we harmonize in situ gene expression and scRNA-seq datasets, allowing transcriptome-wide imputation of spatial gene expression patterns. Our work presents a strategy for the assembly of harmonized references and transfer of information across datasets.
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            Neoantigens in cancer immunotherapy.

            Ton N. Schumacher, Robert D. Schreiber (2015)
            The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the immune system to distinguish cancer cells from noncancer cells has long remained obscure. Recent technological innovations have made it possible to dissect the immune response to patient-specific neoantigens that arise as a consequence of tumor-specific mutations, and emerging data suggest that recognition of such neoantigens is a major factor in the activity of clinical immunotherapies. These observations indicate that neoantigen load may form a biomarker in cancer immunotherapy and provide an incentive for the development of novel therapeutic approaches that selectively enhance T cell reactivity against this class of antigens. Copyright © 2015, American Association for the Advancement of Science.
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              Tumor-infiltrating lymphocytes in the immunotherapy era

              Sterre T Paijens, Annegé Vledder, Marco De Bruyn … (2021)
              Article 0 comments Cited 364 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: Journal of Cancer Research and Clinical Oncology
                Abbreviated Title: J Cancer Res Clin Oncol
                Publisher: Springer Science and Business Media LLC
                ISSN (Print): 0171-5216
                ISSN (Electronic): 1432-1335
                Publication date Created: September 2023
                Publication date (Electronic): May 10 2023
                Publication date (Print): September 2023
                Volume: 149
                Issue: 11
                Pages: 9007-9016
                Article
                DOI: 10.1007/s00432-023-04823-x
                PubMed ID: 37165118
                SO-VID: 0b2de9a6-6b50-4c2a-8ae7-3c934fdddd14
                Copyright © © 2023
                License:

                https://www.springernature.com/gp/researchers/text-and-data-mining

                https://www.springernature.com/gp/researchers/text-and-data-mining

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