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High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden
Ryma Benayed ,
Michael Offin ,
Kerry Mullaney ,
Purvil Sukhadia ,
Kelly Rios ,
Patrice Desmeules ,
Ryan Ptashkin ,
Helen Won ,
Jason Chang ,
Darragh Halpenny ,
Alison M. Schram ,
Charles M. Rudin ,
David M. Hyman ,
Maria E. Arcila ,
Michael F. Berger ,
Ahmet Zehir ,
Mark G. Kris ,
Alexander Drilon ,
Marc Ladanyi
April 26 2019
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Abstract
Targeted next-generation sequencing of DNA has become more widely used in the management
of patients with lung adenocarcinoma; however, no clear mitogenic driver alteration
is found in some cases. We evaluated the incremental benefit of targeted RNA sequencing
(RNAseq) in the identification of gene fusions and MET exon 14 (METex14) alterations
in DNA sequencing (DNAseq) driver-negative lung cancers.