Contributors
Justin M. Gregory:
ORCID: https://orcid.org/0000-0003-2700-0062
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
VisualizationRole: Writing – original draft
Guillaume Kraft: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Chiara Dalla Man: Role: Formal analysisRole: MethodologyRole: SoftwareRole: Writing – review & editing
James C. Slaughter: Role: Formal analysisRole: MethodologyRole: SoftwareRole: Writing – review & editing
Melanie F. Scott: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Jon R. Hastings: Role: InvestigationRole: Project administrationRole: Writing – review & editing
Dale S. Edgerton: Role: Formal analysisRole: MethodologyRole: Writing – review & editing
Mary C. Moore: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: Methodology
Alan D. Cherrington: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: SupervisionRole: Writing – review & editing
Chikezie Hart Onwukwe: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLOS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
22
December
2023
Publication date Collection: 2023
Volume: 18
Issue: 12
Electronic Location Identifier: e0296400
Affiliations
[1
]
Ian Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School
of Medicine, Nashville, TN, United States of America
[2
]
Department of Molecular Physiology and Biophysics, Vanderbilt University School of
Medicine, Nashville, TN United States of America
[3
]
Department of Information Engineering, University of Padova, Padova, Italy
[4
]
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN,
United States of America
Isawiya General Hospital, Governorate of Gurayyat, SAUDI ARABIA
Author notes
Competing Interests: Justin Gregory has served as an advisory board member for Sanofi, Eli Lilly, Medtronic,
Dompe, vTv Therapeutics, and Mannkind Corporation and in data and safety monitoring
roles for vTv Therapeutics and Medtronic. Alan Cherrington is a scientific advisor,
consultant, and holds stock in Fractyl Laboratories. He also holds stock in Metavention.
The other authors have declared that no competing interests exist. This does not alter
our adherence to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-23-29774
DOI: 10.1371/journal.pone.0296400
PMC ID: 10745172
PubMed ID: 38134122
SO-VID: 0a5011ff-1ab0-40c2-859b-8375d7a3b2ec
Copyright © © 2023 Gregory et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 13
September
2023
Date
accepted
: 12
December
2023
Page count
Figures: 6,
Tables: 0,
Pages: 16
Funding
Funded by:
National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes
of Health
Award ID: K23DK123392
Award Recipient
:
ORCID: https://orcid.org/0000-0003-2700-0062
Justin M. Gregory
Funded by:
Vanderbilt Diabetes Research and Training Center
Award ID: DK020593
Award Recipient
:
ORCID: https://orcid.org/0000-0003-2700-0062
Justin M. Gregory
Funded by:
JDRF Career Development Award
Award ID: 5-ECR-2020-950-A-N
Award Recipient
:
ORCID: https://orcid.org/0000-0003-2700-0062
Justin M. Gregory
Funded by:
National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes
of Health
Award ID: R01DK018243
Award Recipient
:
Alan D. Cherrington
Funded by:
Fractyl Health and Metavention
J.M.G. has received career development awards and support from the National Institute
of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health
(K23DK123392), Vanderbilt Diabetes Research and Training Center (DK020593), a JDRF
Career Development Award (5-ECR-2020-950-A-N). A.D.C. has received research funding
from R01DK018243. These studies were drawn from research supported by Fractyl Health
and Metavention. The funders had no role in the study design, data collection and
analysis, decision to publish, or preparation of the manuscript for these experiments.
The contents are solely the responsibility of the authors and do not necessarily represent
official views of the National Institute of Diabetes and Digestive and Kidney Diseases,
the National Institutes of Health, or the JDRF.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Diabetic Endocrinology
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Dogs
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Dogs
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Carbohydrates
Subject:
Monosaccharides
Subject:
Glucose
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Carbohydrates
Subject:
Monosaccharides
Subject:
Glucose
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Pharmacologic-Based Diagnostics
Subject:
Oral Glucose Suppression Test
Subject:
Biology and Life Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Medicine and Health Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Carbohydrate Metabolism
Subject:
Glucose Metabolism
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Glucose Tolerance
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