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Abstract
A wide range of adverse pregnancy outcomes are associated with women of advanced maternal
age (AMA). These include increased risks for miscarriage, chromosomal abnormalities,
stillbirth, foetal growth restriction, preterm birth, pre-eclampsia, gestational diabetes
mellitus and caesarean section. While a wide body of literature has reported on these
risks, varying definitions in both AMA and reported outcomes can make synthesizing
the information difficult when counselling an individual women about her specific
risks. In this chapter, we discuss the role of AMA on adverse pregnancy outcomes with
a view to clarifying the magnitude of the risks for each outcome in the context to
enable more informed clinical counselling and decision-making.
Preterm preeclampsia is an important cause of maternal and perinatal death and complications. It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia.