INTRODUCTION
In 2016, the journal Endocrinology and Metabolism published many excellent articles
in the fields of clinical and basic endocrinology. I believe that these articles contributed
to the increase of scientific knowledge and improvements in the standards of medical
care. Updated information is freely available to readers according to our open-access
policy. I would like to briefly present the excellent articles published in 2016 in
Endocrinology and Metabolism.
ARTICLES ON THYROID DISEASE
Lo et al. [1], from the University of the Philippines, performed a retrospective cohort
study of 723 patients with well-differentiated thyroid cancer, evaluating their clinicopathologic
profiles, ultrasound features, management, tumor recurrence, and eventual outcome
over a mean follow-up period of 5 years. Follicular thyroid cancer among Filipinos
appeared to behave similarly to other racial groups.
Jeon et al. [2] evaluated the significance of telomerase reverse transcriptase (TERT)
promoter mutations in Korean patients with classic papillary thyroid cancer (PTC).
The prevalence of somatic TERT promoter mutations was low in Korean patients with
classic PTC. Therefore, the prognostic role of TERT promoter mutations may be limited
in this patient cohort.
Jauculan et al. [3] identified risk factors for recurrence in the Philippine population
that could potentially be used to identify individuals for whom radioactive iodine
(RAI) therapy might be beneficial. They concluded that a tumor diameter ≥2 cm and
a family history of PTC were significant predictors of recurrence. RAI therapy and
low initial titers of thyroglobulin (Tg) and anti-Tg antibody were significant protective
factors against disease recurrence among low-risk PTC patients. Park et al. [4] evaluated
the genetic predisposition to thyrotoxic periodic paralysis (TPP) in terms of the
β2-adrenergic receptor, androgen receptor, and γ-aminobutyric acid receptor α3 subunit
genes and found no associations of these polymorphisms with TPP. In another article,
doctors from the University of the Philippines also reported that fixed-dose radioiodine
was associated with a significantly lower incidence of persistent hyperthyroidism
at 6 months after radioactive therapy for the treatment of Graves disease [5]. In
an excellent review, Moon [6] comprehensively presented the epidemiological evidence
for the associations between cognitive impairment and several endocrine risk factors,
including insulin resistance, dyslipidemia, thyroid dysfunction, vitamin D deficiency,
and subclinical atherosclerosis. Wiersinga [7], the editor-in-chief of European Thyroid
Journal, presented a review titled ‘Clinical relevance of environmental factors in
the pathogenesis of autoimmune thyroid disease.’ He concluded that stress may provoke
Graves hyperthyroidism but not Hashimoto thyroiditis. Estrogen use has been linked
to a lower prevalence of Graves disease. Kwon et al. [8] evaluated the usefulness
of measuring thyroid-stimulating antibody at the time of anti-thyroid drug withdrawal
for predicting relapse of Graves disease. Kim et al. [9] reported that serum triiodothyronine
levels were independently associated with metabolic syndrome in 13,496 euthyroid middle-aged
subjects. They proposed that longitudinal studies are needed to define this association
and its potential health implications.
In the September issue of Endocrinology and Metabolism, special reviews on thyroid
diseases were published [10
11
12
13]. Of particular note, Yi [10] introduced the revised 2016 Korean Thyroid Association
guidelines for thyroid nodules and cancers, focusing on the differences from the 2015
American Thyroid Association guidelines in her review. Other reviews and original
articles on thyroid disease also appeared in 2016 [14
15].
ARTICLES ON DIABETES, OBESITY, AND LIPID DISORDERS
Choi [16] received the Namgok Award for his work in October 2015, and wrote an excellent
review on the impact of organokines on insulin resistance, inflammation, and atherosclerosis.
In this review, he stressed that there is emerging evidence that skeletal muscle and
the liver also function as endocrine organs that secrete myokines and hepatokines,
respectively. Lee et al. [17] wrote a review about how to establish clinical prediction
models. They summarized five steps for developing and validating a clinical prediction
model: preparation for establishing clinical prediction models, dataset selection,
handling variables, model generation, and model evaluation and validation. Oh [18]
presented a beautiful review about in vivo models for incretin research. She stressed
that robust increases in endogenous incretin secretion have been observed in many
types of metabolic/bariatric surgery. Therefore, metabolic/bariatric surgery has been
extensively studied to elucidate incretin physiology, with a focus not only on the
hormones themselves but also alterations in the distribution of enteroendocrine cells
and genetic expression levels of gut hormones. Hong et al. [19] studied the effects
of short-term exenatide treatment on aortic pulse wave velocity (PWV) in obese type
2 diabetes mellitus (T2DM) patients. They found that short term exenatide use in obese
T2DM patients at high risk in terms of cardiometabolic risk factors not only reduced
body weight without muscle mass loss or changes in body fat mass, but also improved
aortic PWV in accordance with the waist-to-hip ratio. Lee et al. [20] published an
elegant study entitled ‘The relationship between 10-year cardiovascular risk calculated
using the pooled cohort equation and the severity of non-alcoholic fatty liver disease,’
and found that among 15,913 participants, increased severity of non-alcoholic fatty
liver disease showed a higher correlation with estimated 10-year cardiovascular disease
risk when calculated using the pooled cohort equation than when calculated using the
Framingham risk score. Tokatli et al. [21] reported the interesting electrocardiographic
finding of a prolonged peak and end of the T wave interval in patients with T2DM,
and Lee et al. [22] reported the effect of pitavastatin treatment on apolipoprotein
B-48 and lipoprotein-associated phospholipase A2 in patients with metabolic syndrome
in a randomized controlled study. Son et al. [23] published the associations of waist-height
ratio with diabetes risk in a 4-year longitudinal retrospective study. Suh et al.
[24] reported that glucose-dependent insulinotropic peptide levels were associated
with the development of T2DM in a nested case-control study conducted in a Korean
cohort. Bae et al. [25] reported the effects of dipeptidyl peptidase-4 (DPP-4) inhibitors
on hyperglycemia and blood cyclosporine levels in renal transplant patients with diabetes.
In the second issue of 2016, special reviews about diabetes were published [26
27
28
29
30]. Bae [27] reviewed the cardiovascular safety of diabetic drugs, and Kang and Jung
[30] reviewed the cardiovascular effects of glucagon-like peptide-1 receptor agonists.
Many articles on the topic of diabetes and obesity were published in the remaining
issues of 2016 [31
32
33
34
35
36
37
38
39
40
41
42].
ARTICLES ON BONE, ADRENAL, AND OTHER ENDOCRINE DISEASES
Elegant and excellent works were published on the topic of bone, adrenal, and other
endocrine diseases. Choi [43] reviewed the use of dual-energy X-ray absorptiometry
beyond bone mineral density (BMD) determination in the March issue of this year. Choi
et al. [44] reported in an original article that serum γ-glutamyl transferase was
inversely associated with BMD independently of alcohol consumption. Kim and Cho [45]
reported that high levels of serum DPP-4 activity were associated with low BMD in
obese postmenopausal women. They found that serum DPP-4 activity was positively correlated
with serum calcium concentrations, intact parathyroid hormone, and serum C-telopeptide
levels. In the third issue of 2016, an original article was published about osteoporosis
and the prevalence of fractures among adult Filipino men screened for BMD in a tertiary
hospital [46]. They reported that of the 184 Filipino male patients, 40.2% and 29.9%
had osteopenia and osteoporosis, respectively. Approximately 22% of osteopenic men
and 32% of osteoporotic men had fragility fractures of the hip, spine, or forearm,
a very high prevalent fracture rate. Kim et al. [47] reported the association of higher
plasma macrophage migration inhibitory factor (MIF) levels with lower BMD and higher
bone turnover rate in postmenopausal women. In their cross-sectional study, the odds
ratio per each standard deviation increment of MIF levels for osteoporosis was 1.32
(95% confidence interval, 1.01 to 1.73). Another review and an original article on
bone disease also appeared in 2016 [48
49].
Many interesting articles were published on the topic of adrenal disease. Lee et al.
[50] reported the radiographic characteristics of adrenal masses in oncologic patients
in the first issue of 2016. From 2000 to 2012, 131 oncologic patients with adrenal
incidentalomas were reviewed retrospectively. The receiver operating characteristic
curve results suggested that pre-contrast levels of >20 Hounsfield units can be used
as a diagnostic reference to suggest metastasis in oncologic patients with adrenal
masses. In another original article, the recovery rate of adrenal function in patients
with glucocorticoid (GC)-induced secondary adrenal insufficiency (AI) was reported
[51]. Adrenal function recovery was frequently achieved in patients with GC-induced
secondary AI within 1 to 2 years. Additionally, an incremental cortisol response at
the first short Synacthen test may be an important predictive factor of adrenal function
recovery. Kim et al. [52] reported the diagnostic role of the captopril challenge
test (CCT) in Korean subjects with a high aldosterone-to-renin ratio (ARR). A cut-off
value of 13 ng/dL showed the highest diagnostic odds ratio considering plasma aldosterone
concentration at 60 and 90 minutes post-CCT, and they concluded that the CCT test
may be a reliable post-screening test to avoid hospitalization in the setting of falsely
elevated ARR screening tests. Kim et al. [53] reported that the recovery of the hypothalamic-pituitary-adrenal
axis was rapid in patients with subclinical Cushing syndrome. The probability of recovering
adrenal function during follow-up differed significantly between patients with overt
Cushing syndrome and subclinical Cushing syndrome, with significant correlations with
the degree of preoperative cortisol excess. Han et al. [54] reported the prevalence
of obesity and hyperglycemia in Korean men with Klinefelter syndrome in a Korean Endocrine
Society Registry. The prevalence of obesity, defined as a body mass index ≥25 kg/m2
in Korean men with Klinefelter syndrome, was 42.6%, and testosterone levels were an
independent risk factor for obesity and hyperglycemia.
ARTICLES ON BASIC RESEARCH
Kim et al. [55] wrote an elegant review of metabolomics in biomedical research. They
reported that the transcriptome does not always correlate with the proteome and that
the translated proteome might not be functionally active. Therefore, changes in the
transcriptome and translated proteome do not always result in phenotypic alterations.
Unlike the genome or proteome, the metabolome is often called the molecular phenotype
of living organisms, and is easily translated into biological conditions and disease
states. Yuk et al. [56] wrote a review about small heterodimer partner and innate
immune regulation. In another review article, the mechanisms of vascular calcification
focusing on the pivotal role of pyruvate dehydrogenase kinase 4 (PDK4) were presented
[57]. Recent studies were summarized, showing that PDK4 is an attractive therapeutic
target for the treatment of various metabolic diseases. Liu and Herbison [58] reviewed
kisspeptin regulation of neuronal activity throughout the central nervous system.
They provided a review of kisspeptin actions on neuronal populations throughout the
brain, including the magnocellular oxytocin and vasopressin neurons, and cells within
the arcuate nucleus, hippocampus, and amygdala. Kang [59] presented a beautiful review,
entitled ‘Dissecting tumor-stromal interactions in breast cancer bone metastasis.’
He showed that the elevated expression of vascular cell adhesion molecule 1 in disseminated
breast tumor cells mediated the recruitment of pre-osteoclasts and promoted their
differentiation to mature osteoclasts during bone metastasis formation. Ku et al.
[60] reported the effects of a high-fat diet and resveratrol on mitochondrial activity
in brown adipocytes in an original work. Resveratrol improved insulin resistance,
which might be associated with the mitochondrial activity of brown adipocytes. Gavrieli
and Mantzoros [61] presented a review of novel molecules regulating energy homeostasis.
CONCLUSIONS
In this editorial, I would like to thank all the scientists who have devoted their
effort to Endocrinology and Metabolism. I am deeply grateful to all readers, authors,
and editors, and to the board members of the Korean Endocrine Society. Their sincere
support made it possible to publish many excellent articles. I would like to specially
thank Prof. Eun-Jung Rhee, one of our deputy editors, and Hye Yeon Jang, the manuscript
editor of the Korean Endocrine Society. I hope that readers will benefit from Endocrinology
and Metabolism.