Tumor-infiltrating lymphocyte quantification stratifies early-stage human papillomavirus oropharynx cancer prognosis.

Faraji, Farhoud; Fung, Nicholas; Zaidi, Munfarid; Gourin, Christine C; Eisele, David W.; Rooper, Lisa M; Fakhry, Carole

doi:10.1002/lary.28044

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Tumor-infiltrating lymphocyte quantification stratifies early-stage human papillomavirus oropharynx cancer prognosis.

Author(s): Farhoud Faraji ¹ , Nicholas Fung ² , Munfarid Zaidi ² , Christine C Gourin ² , David W Eisele ² , Lisa M Rooper ³ , Carole Fakhry ² ^, ⁴ ^, ⁵

Publication date (Electronic): April 2020

Journal: The Laryngoscope

Publisher: Wiley

Keywords: Oropharynx, human papillomavirus, prognosis, squamous cell carcinoma, tumor infiltrating lymphocyte

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Abstract

To evaluate if a simple method for assessing tumor-infiltrating lymphocytes (TIL) in primary tumor specimens improves the prognostic value of the American Joint Committee on Cancer, 8th Edition (AJCC8) cancer staging system in human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPC).

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Journal ID (iso-abbrev): Laryngoscope

Title: The Laryngoscope

Publisher: Wiley

ISSN (Electronic): 1531-4995

ISSN (Print): 0023-852X

Publication date (Electronic): April 2020

Volume: 130

Issue: 4

Affiliations

[1 ] Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California.

[2 ] Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.

[3 ] Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland.

[4 ] Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland.

[5 ] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, U.S.A.

Article

DOI: 10.1002/lary.28044

PubMed ID: 31070246

SO-VID: 0946cfa1-22d7-49cb-9d46-eb9ed8b874c4

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Keywords: prognosis,Oropharynx,squamous cell carcinoma,human papillomavirus,tumor infiltrating lymphocyte

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Keywords: prognosis, Oropharynx, squamous cell carcinoma, human papillomavirus, tumor infiltrating lymphocyte

Tumor-infiltrating lymphocyte quantification stratifies early-stage human papillomavirus oropharynx cancer prognosis.

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