Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
10
May
2022
Publication date Collection: 2022
Volume: 17
Issue: 5
Electronic Location Identifier: e0268223
Affiliations
[1
]
Centre for OA Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, University
of Oxford, Oxford, United Kingdom
[2
]
Diamond Light Source Ltd, Diamond House, Harwell Science and Innovation Campus, Didcot,
United Kingdom
[3
]
Target Discovery Institute, Nuffield Department of Medicine Research Building, University
of Oxford, Oxford, United Kingdom
University of Patras, GREECE
Author notes
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following
competing interests: MMF and NHL are named inventors on patents for radiopaque compounds
containing DIT (WO2018020262A1, EP3490614A1). All other authors declare that they
have no competing interests.
Author information
Article
Publisher ID:
PONE-D-21-34457
DOI: 10.1371/journal.pone.0268223
PMC ID: 9089912
PubMed ID: 35536857
SO-VID: 0936e613-4ead-44f6-b160-00c5d1f45697
Copyright © © 2022 Fowkes et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/501100000849, National Centre for the Replacement, Refinement and Reduction of Animals in Research;
Award ID: NC/M000141/1
Award Recipient
:
Ngee H. Lim
Funded by:
funder-id http://dx.doi.org/10.13039/501100012041, Versus Arthritis;
Award ID: 20205
Funded by:
funder-id http://dx.doi.org/10.13039/501100012041, Versus Arthritis;
Award ID: 21621
This work was supported by the National Centre for the Replacement, Refinement and
Reduction of Animals in Research (NC3R grant NC/M000141/1, NHL,
https://www.nc3rs.org.uk/) and the Centre for OA Pathogenesis Versus Arthritis (Versus Arthritis grants 20205,
21621,
https://www.versusarthritis.org/). The human tissue work was supported by the National Institute for Health Research
(NIHR) via the Oxford Biomedical Research Centre. The funders had no role in study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Articular Cartilage
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Articular Cartilage
Subject:
Medicine and Health Sciences
Subject:
Rheumatology
Subject:
Arthritis
Subject:
Osteoarthritis
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Skeleton
Subject:
Tibia
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Skeleton
Subject:
Tibia
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Diagnostic Radiology
Subject:
Magnetic Resonance Imaging
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
Diagnostic Radiology
Subject:
Magnetic Resonance Imaging
Subject:
Medicine and Health Sciences
Subject:
Radiology and Imaging
Subject:
Diagnostic Radiology
Subject:
Magnetic Resonance Imaging
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Collagens
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Diagnostic Radiology
Subject:
Bone Imaging
Subject:
X-Ray Radiography
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
Diagnostic Radiology
Subject:
Bone Imaging
Subject:
X-Ray Radiography
Subject:
Medicine and Health Sciences
Subject:
Radiology and Imaging
Subject:
Diagnostic Radiology
Subject:
Bone Imaging
Subject:
X-Ray Radiography
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Diagnostic Radiology
Subject:
X-Ray Radiography
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
Diagnostic Radiology
Subject:
X-Ray Radiography
Subject:
Medicine and Health Sciences
Subject:
Radiology and Imaging
Subject:
Diagnostic Radiology
Subject:
X-Ray Radiography
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
In Vivo Imaging