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      The epidemiology and impact of pain in osteoarthritis.

      1
      Osteoarthritis and cartilage
      Elsevier BV
      Osteoarthritis, Pain, Risk factors

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          Abstract

          Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide, largely due to pain, the primary symptom of the disease. The pain experience in knee OA in particular is well-recognized as typically transitioning from intermittent weight-bearing pain to a more persistent, chronic pain. Methods to validly assess pain in OA studies have been developed to address the complex nature of the pain experience. The etiology of pain in OA is recognized to be multifactorial, with both intra-articular and extra-articular risk factors. Nonetheless, greater insights are needed into pain mechanisms in OA to enable rational mechanism-based management of pain. Consequences of pain related to OA contribute to a substantial socioeconomic burden.

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          Author and article information

          Journal
          Osteoarthritis Cartilage
          Osteoarthritis and cartilage
          Elsevier BV
          1522-9653
          1063-4584
          Sep 2013
          : 21
          : 9
          Affiliations
          [1 ] Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA. tneogi@bu.edu
          Article
          S1063-4584(13)00760-7 NIHMS479319
          10.1016/j.joca.2013.03.018
          3753584
          23973124
          07dc10e8-4a06-4ae4-9021-5a62f30d1189
          Copyright © 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
          History

          Osteoarthritis,Pain,Risk factors
          Osteoarthritis, Pain, Risk factors

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