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      • Record: found
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      Antifertility activity of Cryptolepis sanguinolenta leaf ethanolic extract in male rats

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          Abstract

          BACKGROUND:

          Complementary medicine has grown over time with more botanicals emerging and remaining integral parts of medicare. Such botanicals include Cryptolepis sanguinolenta.

          AIM:

          This study investigated the effect of Cryptolepis sanguinolenta leaf ethanolic extract on male reproductive system using rat model.

          MATERIALS AND METHODS:

          Control and treated rats were maintained on control diet. Treated rats also received graded doses of the extract.

          RESULTS:

          When compared with the controls, Cryptolepis sanguinolenta treatment led to significant testosterone suppression associated with consequent significant rise in luteinizing hormone (LH) and decrease in sperm count. Treatment with Cryptolepis sanguinolenta did not result in significant attenuation of follicular stimulating hormone (FSH) levels and testicular morphometry. Sperm viability, motility, and morphology were also comparable in all groups.

          CONCLUSION:

          These results suggest that Cryptolepis sanguinolenta possesses anti-androgenic and anti-spermatogenic properties with potential anti-aphrodisiac activity.

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          Most cited references72

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          In vitro and in vivo antiplasmodial activity of cryptolepine and related alkaloids from Cryptolepis sanguinolenta.

          C Turger, Joana de Oliveira, A Vlietinck … (1997)
          Three different extracts and four alkaloids from the root bark of Cryptolepis sanguinolenta have been assessed in vitro against Plasmodium falciparum D-6 (chloroquine-sensitive strain), K-1, and W-2 (chloroquine-resistant strains). Cryptolepine (1) and its hydrochloride (2), 11-hydroxycryptolepine (3), and neocryptolepine (5) showed a strong antiplasmodial activity against P. falciparum chloroquine-resistant strains. Quindoline (4) was less active. The highest activity was obtained with compound 1. In vivo tests on infected mice showed that cryptolepine (1), when tested as its hydrochloride (2), exhibited a significant chemosuppressive effect against Plasmodium berghei yoelii and Plasmodium berghei, berghei, while 1 had the same effect against P. berghei yoelii only. Compounds 3 and 4 did not show activity in this in vivo test system.
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            The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.

            L Angenot, M.-P. Defresne, Michel de Garine-Wichatitsky … (1998)
            Cryptolepine hydrochloride is an indoloquinoline alkaloid isolated from the roots of Cryptolepis sanguinolenta. It is characterized by a multiplicity of host-mediated biological activities, including antibacterial, antiviral, and antimalarial properties. To date, the molecular basis for its diverse biological effects remains largely uncertain. Several lines of evidence strongly suggest that DNA might correspond to its principal cellular target. Consequently, we studied the strength and mode of binding to DNA of cryptolepine by means of absorption, fluorescence, circular, and linear dichroism, as well as by a relaxation assay using DNA topoisomerases. The results of various optical and gel electrophoresis techniques converge to reveal that the alkaloid binds tightly to DNA and behaves as a typical intercalating agent. In DNAase I footprinting experiments it was found that the drug interacts preferentially with GC-rich sequences and discriminates against homo-oligomeric runs of A and T. This study has also led to the discovery that cryptolepine is a potent topoisomerase II inhibitor and a promising antitumor agent. It stabilizes topoisomerase II-DNA covalent complexes and stimulates the cutting of DNA at a subset of preexisting topoisomerase II cleavage sites. Taking advantage of the fluorescence of the indoloquinoline chromophore, fluorescence microscopy was used to map cellular uptake of the drug. Cryptolepine easily crosses the cell membranes and accumulates selectively into the nuclei rather than in the cytoplasm of B16 melanoma cells. Quantitative analyses of DNA in cells after Feulgen reaction and image cytometry reveal that the drug blocks the cell cycle in G2/M phases. It is also shown that the alkaloid is more potent at inhibiting DNA synthesis rather than RNA and protein synthesis. Altogether, the results provide direct evidence that DNA is the primary target of cryptolepine and suggest that this alkaloid is a valid candidate for the development of tumor active compounds.
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              Plants used in home medicine in the Zenta River basin, Northwest Argentina.

              N.I. Hilgert (2001)
              The use of herbal pharmacopoeia in the domestic life of a rural community in the west of the Orán Department, Salta Province, Argentina is reported in this article. One hundred and seventeen plant species belonging to 52 families and 98 different genera were included. Their vernacular name, popular use, administration, used parts and ways of obtaining are given. It is concluded that home medicine constitutes a relevant resource in the area.
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Hum Reprod Sci
                Journal ID (iso-abbrev): J Hum Reprod Sci
                Journal ID (publisher-id): JHRS
                Title: Journal of Human Reproductive Sciences
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 0974-1208
                ISSN (Electronic): 1998-4766
                Publication date (Print): Jan-Apr 2012
                Volume: 5
                Issue: 1
                Pages: 43-47
                Affiliations
                [1]Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
                Author notes
                Address for correspondence: Mr. RE Akhigbe, Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria E-mail: akhigbemcroy@ 123456yahoo.com
                Article
                Publisher ID: JHRS-5-43
                DOI: 10.4103/0974-1208.97799
                PMC ID: 3409919
                PubMed ID: 22870014
                SO-VID: 07d298f6-bd80-43a9-ba34-b83206da5449
                Copyright © Copyright: © Journal of Human Reproductive Sciences
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 27 December 2011
                Date revision received : 20 February 2012
                Date accepted : 07 March 2012
                Categories
                Subject: Original Article

                ScienceOpen disciplines: Human biology
                Keywords: fsh,testosterone,sperm,lh,cryptolepis sanguinolenta,testes
                Data availability:
                ScienceOpen disciplines: Human biology
                Keywords: fsh, testosterone, sperm, lh, cryptolepis sanguinolenta, testes

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