For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
16
views
69
references
 Top references
cited by
30
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      351
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Emerging insights into recurrent and metastatic human papillomavirus‐related oropharyngeal squamous cell carcinoma

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          ABSTRACT

          Objective

          To review recent literature on human papillomavirus‐related (HPV‐positive) oropharyngeal squamous cell carcinoma (OPC) and focus on implications of recurrent and metastatic disease.

          Methods

          Primary articles from 1990 to 2016 indexed in MEDLINE (1) pertaining to the epidemiology of HPV‐positive OPC and (2) providing clinical insight into recurrent and metastatic OPC.

          Results

          The incidence of HPV‐positive OPC is increasing globally. HPV‐positive OPC is a subtype with distinct molecular and clinical features including enhanced treatment response and improved overall survival. While disease recurrence is less common in patients with HPV‐positive OPC, up to 36% of patients experience treatment failure within eight years. Recurrent and metastatic OPC has historically signified poor prognosis, however recent data are challenging this dogma. Here, we discuss recurrent and metastatic OPC in the context of HPV tumor status.

          Conclusion

          HPV‐positive OPC exhibits distinct genetic, cellular, epidemiological, and clinical features from HPV‐negative OPC. HPV tumor status is emerging as a marker indicative of improved prognosis after disease progression in both locoregionally recurrent and distant metastatic OPC.

          Level of Evidence

          N/A.

          Related collections

          Most cited references69

          • Record: found
          • Abstract: found
          • Article: not found

          Models, mechanisms and clinical evidence for cancer dormancy.

          Julio Aguirre-Ghiso (2007)
          Patients with cancer can develop recurrent metastatic disease with latency periods that range from years even to decades. This pause can be explained by cancer dormancy, a stage in cancer progression in which residual disease is present but remains asymptomatic. Cancer dormancy is poorly understood, resulting in major shortcomings in our understanding of the full complexity of the disease. Here, I review experimental and clinical evidence that supports the existence of various mechanisms of cancer dormancy including angiogenic dormancy, cellular dormancy (G0-G1 arrest) and immunosurveillance. The advances in this field provide an emerging picture of how cancer dormancy can ensue and how it could be therapeutically targeted.
          Article 0 comments Cited 531 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            p53 mutations in human cancers.

            M Hollstein, D Sidransky, B Vogelstein … (1991)
            Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer. The p53 mutational spectrum differs among cancers of the colon, lung, esophagus, breast, liver, brain, reticuloendothelial tissues, and hemopoietic tissues. Analysis of these mutations can provide clues to the etiology of these diverse tumors and to the function of specific regions of p53. Transitions predominate in colon, brain, and lymphoid malignancies, whereas G:C to T:A transversions are the most frequent substitutions observed in cancers of the lung and liver. Mutations at A:T base pairs are seen more frequently in esophageal carcinomas than in other solid tumors. Most transitions in colorectal carcinomas, brain tumors, leukemias, and lymphomas are at CpG dinucleotide mutational hot spots. G to T transversions in lung, breast, and esophageal carcinomas are dispersed among numerous codons. In liver tumors in persons from geographic areas in which both aflatoxin B1 and hepatitis B virus are cancer risk factors, most mutations are at one nucleotide pair of codon 249. These differences may reflect the etiological contributions of both exogenous and endogenous factors to human carcinogenesis.
            Article 0 comments Cited 488 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review

              A. Kreimer (2005)
              Mucosal human papillomaviruses (HPV) are the cause of cervical cancer and likely a subset of head and neck squamous cell carcinomas (HNSCC), yet the global prevalence and type distribution of HPV in HNSCC remains unclear. We systematically reviewed published studies of HNSCC biopsies that employed PCR-based methods to detect and genotype HPV to describe the prevalence and type distribution of HPV by anatomic cancer site. Geographic location and study size were investigated as possible sources of variability. In the 5,046 HNSCC cancer specimens from 60 studies, the overall HPV prevalence was 25.9% [95% confidence interval (95% CI), 24.7-27.2]. HPV prevalence was significantly higher in oropharyngeal SCCs (35.6% of 969; 95% CI, 32.6-38.7) than oral SCCs (23.5% of 2,642; 95% CI, 21.9-25.1) or laryngeal SCCs (24.0% of 1,435; 95% CI, 21.8-26.3). HPV16 accounted for a larger majority of HPV-positive oropharyngeal SCCs (86.7%; 95% CI, 82.6-90.1) compared with HPV-positive oral SCCs (68.2%; 95% CI, 64.4-71.9) and laryngeal SCCs (69.2%; 95% CI, 64.0-74.0). Conversely, HPV18 was rare in HPV-positive oropharyngeal SCCs (2.8%; 95% CI, 1.3-5.3) compared with other head and neck sites [34.1% (95% CI, 30.4-38.0) of oral SCCs and 17.0% (95% CI, 13.0-21.6) of laryngeal SCCs]. Aside from HPV16 and HPV18, other oncogenic HPVs were rarely detected in HNSCC. Tumor site-specific HPV prevalence was higher among studies from North America compared with Europe and Asia. The high HPV16 prevalence and the lack of HPV18 in oropharyngeal compared with other HNSCCs may point to specific virus-tissue interactions. Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx.
              Article 0 comments Cited 470 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Carole Fakhry: cfakhry@jhmi.edu
                Journal
                Journal ID (nlm-ta): Laryngoscope Investig Otolaryngol
                Journal ID (iso-abbrev): Laryngoscope Investig Otolaryngol
                Journal ID (doi): 10.1002/(ISSN)2378-8038
                Journal ID (publisher-id): LIO2
                Title: Laryngoscope Investigative Otolaryngology
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 2378-8038
                Publication date (Electronic): 17 January 2017
                Publication date Collection: February 2017
                Volume: 2
                Issue: 1 ( doiID: 10.1002/lio2.v2.1 )
                Pages: 10-18
                Affiliations
                [ 1 ] Department of Otolaryngology‐Head and Neck Surgery Johns Hopkins University School of Medicine Baltimore Maryland
                [ 2 ] Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland
                Author notes
                [*] [* ]Send correspondence to Carole Fakhry, MD, MPH, Johns Hopkins University School of Medicine, Otolaryngology‐Head and Neck Surgery, 601 N. Caroline Street, Sixth Floor, Baltimore, MD 21287. Fax: (410) 955‐6526. E‐mail: cfakhry@ 123456jhmi.edu
                Article
                Publisher ID: LIO237
                DOI: 10.1002/lio2.37
                PMC ID: 5510283
                PubMed ID: 28894817
                SO-VID: 07a0a710-74dc-483c-82f8-477ceb05bdc3
                Copyright © © 2017 The Authors Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society
                License:

                This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                Date received : 19 September 2016
                Date accepted : 06 October 2016
                Page count
                Figures: 3, Tables: 0, Pages: 9, Words: 8235
                Categories
                Subject: Head and Neck, and Tumor Biology
                Subject: Head and Neck, and Tumor Biology
                Subject: Review Article
                Custom metadata
                source-schema-version-number 2.0
                component-id lio237
                cover-date February 2017
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_NLMPMC version:5.1.4 mode:remove_FC converted:26.07.2017

                Keywords: head and neck,squamous cell carcinoma,hnscc,human papillomavirus,hpv,oropharyngeal,opscc,recurrent,metastatic,prognosis,survival
                Data availability:
                Keywords: head and neck, squamous cell carcinoma, hnscc, human papillomavirus, hpv, oropharyngeal, opscc, recurrent, metastatic, prognosis, survival

                Comments

                Comment on this article

                scite_

                Similar content351

                See all similar

                Cited by30

                See all cited by