Subjective cognitive decline and rates of incident Alzheimer’s disease and non-Alzheimer’s disease dementia

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Abstract

Introduction:

In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer’s disease (AD) and non-AD dementia and (2) determinants of progression to dementia.

Methods:

Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models.

Results:

In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2–20.3)/1000 person-years (AD: 11.5 [9.6–13.7], non-AD: 6.1 [4.7–7.7]), compared with 14.2 (11.3–17.6) in controls (AD: 10.1 [7.7–13.0], non-AD: 4.1 [2.6–6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1–1.1]), lower Mini-Mental State Examination (0.7 [0.66–0.8]), and apolipoprotein E ε4 (1.8 [1.3–2.5]) increased the risk of dementia.

Discussion:

SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.

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Most cited references 20

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

E H Corder, A M Saunders, W J Strittmatter … (1993)

The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.

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Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease.

Nancy Donovan, Rebecca E Amariglio, Amy S Zoller … (2014)

To examine neuropsychiatric and neuropsychological predictors of progression from normal to early clinical stages of Alzheimer disease (AD).

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Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.

Andrea L. Launer, Cheryl Lobo, L Fratiglioni … (1999)

The authors examined the association of incident dementia and subtypes with age, sex, and geographic area in Europe. Incidence data from eight population-based studies carried out in seven European countries were compared and pooled. The pooled data included 835 mild to severe dementia cases and 42,996 person-years of follow-up. In all studies a higher proportion of cases were diagnosed with AD (60 to 70% of all demented cases) than vascular dementia (VaD). The incidence of dementia and AD continued to increase with age up to age 85 years, after which rates increased in women but not men. There was a large variation in VaD incidence across studies. In the pooled analysis, the incidence rates increased with age without any substantial difference between men and women. Surprisingly, higher incidence rates of dementia and AD were found in the very old in northwest countries than in southern countries. This study confirms that AD is the most frequent dementing disorder in all ages, and that there is a higher incidence of dementia, specifically AD, in women than men among the very old. Finally, there may be regional differences in dementia incidence.

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Author and article information

Journal

Journal ID (nlm-journal-id): 101231978

Journal ID (pubmed-jr-id): 33173

Journal ID (nlm-ta): Alzheimers Dement

Journal ID (iso-abbrev): Alzheimers Dement

Title: Alzheimer's & dementia : the journal of the Alzheimer's Association

ISSN (Print): 1552-5260

ISSN (Electronic): 1552-5279

Publication date Nihms-submitted: 31 March 2019

Publication date (Electronic): 13 December 2018

Publication date (Print): March 2019

Publication date PMC-release: 15 April 2019

Volume: 15

Issue: 3

Pages: 465-476

Affiliations

[a ]Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands

[b ]Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands

[c ]Center for Healthy Brain Ageing and Dementia Centre fo r Research Collaboration, University of New South Wales, Sydney, Australia

[d ]University of Melbourne, Melbourne, Australia

[e ]The Florey Institutes of Neurosciences and Mental Health, Melbourne, Australia

[f ]Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

[g ]AXA Research Fund & Sorbonne University Chair, Paris, France

[h ]Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France

[i ]Brain & Spine Institute (ICM), INSERM U 1127, CNRS UMR 7225, Paris, France

[j ]Institute of Memory and Alzheimer’s Disease (IM2A), Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France

[k ]Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece

[l ]New York University Alzheimer’s Disease Center, NYU Langone Medical Center, New York, NY, USA

[m ]Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia

[n ]Institute of Social Medicine, Occupational Health and Public Health (ISAP), Faculty of Medicine, University of Leipzig, Leipzig, Germany

[o ]Social Psychiatry, Department of Economic and Social Sciences, University of Applied Sciences Nordhausen, Nordhausen, Germany

[p ]Cogstate Ltd., Melbourne, Australia

[q ]Neurology Department, Hospital Clinic i Universitari-IDIBAPS and BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain

[r ]Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany

[s ]Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine Indianapolis, IN, USA

[t ]Indiana Alzheimer Disease Center, Indiana University School of Medicine Indianapolis, IN, USA

[u ]LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany

[v ]National and Kapodistrian University of Athens, Athens, Greece

[w ]Department of Neurology, Columbia University Medical Center, New York, NY, USA

[x ]Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands

[y ]DZNE, German Center for Neurodegenerative Diseases, Germany

[z ]Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany

[aa ]Psychiatry Department, University of Cologne, Cologne, Germany https://doi.org/10.1016/j.jalz.2018.10.003

Author notes

[* ]Corresponding author. Tel.: 131204440816; Fax: 131204448529. wm.vdflier@ 123456vumc.nl

Article

Manuscript ID: NIHMS1021068

DOI: 10.1016/j.jalz.2018.10.003

PMC ID: 6465066

PubMed ID: 30555032

SO-VID: 076e8a4e-18e5-42bf-b45b-ce49e84b3f18

License:

This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Subjective cognitive decline and rates of incident Alzheimer’s disease and non-Alzheimer’s disease dementia

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Abstract

Introduction:

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Results:

Discussion:

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Karger: Neurology and Neuroscience

Most cited references 20

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease.

Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.

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