Association of sudden sensorineural hearing loss with asthma: a longitudinal follow-up study using a national sample cohort

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Abstract

Objective

To investigate the risk of sudden sensorineural hearing loss (SSNHL) in asthma patients.

Design

A longitudinal follow-up study using a retrospective cohort

Setting

The 2002–2013 Korean National Health Insurance Service-Health Screening Cohort

Participants and interventions

The ≥40 years old Korean population were enrolled. The asthma patients were 1:1 matched with the control group for age, sex, income and region of residence.

Main outcome measure

The occurrence of SSNHL was followed in both asthma and control groups. The stratified Cox proportional hazard model was used. Age, sex, income and region of residence were stratified, and Charlson Comorbidity Index scores, obesity, smoking, alcohol consumption and atopic dermatitis histories were adjusted. Subgroup analysis was performed according to age, sex, obesity, smoking and alcohol consumption.

Results

The results showed that 1.0% (877/90 564) of the asthma group and 0.8% (706/90,564) of the control group exhibited SSNHL (p<0.001). The asthma group demonstrated a higher HR for SSNHL than the control group (adjusted HR 1.23, 95% CI 1.11 to 1.36, p<0.001). According to age and sex, the female subgroup showed elevated HRs for SSNHL in asthma patients. Both the non-smoker and current smoker groups demonstrated higher HRs for SSNHL in asthma patients than in controls. According to alcohol consumption or obesity, the <1 time a week alcohol consumption group and normal weight and severe obesity groups showed higher HRs for SSNHL in asthma patients than in the controls.

Conclusions

Adult asthma patients had a higher risk of SSNHL than the control participants matched for demographic and socioeconomic factors.

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Most cited references 45

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Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries.

Hude Quan, Bing Li, Chantal M Couris … (2011)

With advances in the effectiveness of treatment and disease management, the contribution of chronic comorbid diseases (comorbidities) found within the Charlson comorbidity index to mortality is likely to have changed since development of the index in 1984. The authors reevaluated the Charlson index and reassigned weights to each condition by identifying and following patients to observe mortality within 1 year after hospital discharge. They applied the updated index and weights to hospital discharge data from 6 countries and tested for their ability to predict in-hospital mortality. Compared with the original Charlson weights, weights generated from the Calgary, Alberta, Canada, data (2004) were 0 for 5 comorbidities, decreased for 3 comorbidities, increased for 4 comorbidities, and did not change for 5 comorbidities. The C statistics for discriminating in-hospital mortality between the new score generated from the 12 comorbidities and the Charlson score were 0.825 (new) and 0.808 (old), respectively, in Australian data (2008), 0.828 and 0.825 in Canadian data (2008), 0.878 and 0.882 in French data (2004), 0.727 and 0.723 in Japanese data (2008), 0.831 and 0.836 in New Zealand data (2008), and 0.869 and 0.876 in Swiss data (2008). The updated index of 12 comorbidities showed good-to-excellent discrimination in predicting in-hospital mortality in data from 6 countries and may be more appropriate for use with more recent administrative data. © The Author 2011. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.

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Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys

M Innes Asher, Stephen Montefort, Bengt Björkstén … (2006)

Data for trends in prevalence of asthma, allergic rhinoconjunctivitis, and eczema over time are scarce. We repeated the International Study of Asthma and Allergies in Childhood (ISAAC) at least 5 years after Phase One, to examine changes in the prevalence of symptoms of these disorders. For the ISAAC Phase Three study, between 2002 and 2003, we did a cross-sectional questionnaire survey of 193,404 children aged 6-7 years from 66 centres in 37 countries, and 304,679 children aged 13-14 years from 106 centres in 56 countries, chosen from a random sample of schools in a defined geographical area. Phase Three was completed a mean of 7 years after Phase One. Most centres showed a change in prevalence of 1 or more SE for at least one disorder, with increases being twice as common as decreases, and increases being more common in the 6-7 year age-group than in the 13-14 year age-group, and at most levels of mean prevalence. An exception was asthma symptoms in the older age-group, in which decreases were more common at high prevalence. For both age-groups, more centres showed increases in all three disorders more often than showing decreases, but most centres had mixed changes. The rise in prevalence of symptoms in many centres is concerning, but the absence of increases in prevalence of asthma symptoms for centres with existing high prevalence in the older age-group is reassuring. The divergent trends in prevalence of symptoms of allergic diseases form the basis for further research into the causes of such disorders.

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The Cytokines of Asthma

Bart N. Lambrecht, Hamida Hammad, John Fahy (2019)

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Here, we review the cytokine networks driving asthma, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic. We discuss established and emerging paradigms in the context of the growing appreciation of disease heterogeneity and argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.

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Author and article information

Journal

Journal ID (nlm-ta): BMJ Open

Journal ID (iso-abbrev): BMJ Open

Journal ID (hwp): bmjopen

Journal ID (publisher-id): bmjopen

Title: BMJ Open

Publisher: BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )

ISSN (Electronic): 2044-6055

Publication date Collection: 2022

Publication date (Electronic): 1 February 2022

Volume: 12

Issue: 2

Electronic Location Identifier: e047966

Affiliations

[1 ]departmentDepartment of Otorhinolaryngology-Head & Neck Surgery , Hallym University , Anyang-si, Republic of Korea

[2 ]Hallym University Sacred Heart Hospital , Anyang, Gyeonggi-do, Republic of Korea

[3 ]departmentDepartment of Otorhinolaryngology-Head & Neck Surgery , CHA University , Pocheon, Republic of Korea

[4 ]departmentDepartment of Otorhinolaryngology-Head & Neck Surgery , Hallym University College of Medicine , Chuncheon, Republic of Korea

Author notes

[Correspondence to ] Professor So Young Kim; sossi81@ 123456hanmail.net

Author information

Hyo Geun Choi http://orcid.org/0000-0003-1655-9549

So Young Kim http://orcid.org/0000-0002-7361-4930

Article

Publisher ID: bmjopen-2020-047966

DOI: 10.1136/bmjopen-2020-047966

PMC ID: 8808386

PubMed ID: 35105562

SO-VID: 07005fcc-456a-48fb-adc3-5c2c975b003e

License:

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

History

Date received : 15 December 2020

Date accepted : 22 December 2021

Funding

Funded by: National Research Foundation (NRF) of Korea;

Award ID: 2021-R1C1C1004986

Funded by: FundRef http://dx.doi.org/10.13039/501100003725, National Research Foundation of Korea;

Award ID: NRF- 2020R1A2C4002594

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ScienceOpen disciplines: Medicine

Keywords: asthma,epidemiology,neurotology

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ScienceOpen disciplines: Medicine

Keywords: asthma, epidemiology, neurotology

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Association of sudden sensorineural hearing loss with asthma: a longitudinal follow-up study using a national sample cohort

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Abstract

Objective

Design

Setting

Participants and interventions

Main outcome measure

Results

Conclusions

Related collections

AIP Publishing: Coronavirus

Most cited references 45

Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries.

Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys

The Cytokines of Asthma

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Cited by 2

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