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      Prevention of post-contrast kidney injury in patients with cancer

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          Abstract

          Post-contrast acute kidney injury is defined as a nephropathy with an increase in serum creatinine of >0.3 mg/dL (or >26.5 μmol/L) or >1.5-times the baseline within 48–72 h of intravascular administration of a contrast medium. Patients with cancer have an increased risk of post-contrast acute kidney injury not only related to the frequent use of contrast medium for computed tomography scans but also to other factors, including the type of tumour, age, oncological therapies, use of other nephrotoxic agents and dehydration. Preventive strategies were developed and may be applied to different risk profiles. Patients at risk may be detected by recently published risk scores.

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          Notice

          Vlado Perkovic (2012)
          SECTION I: USE OF THE CLINICAL PRACTICE GUIDELINE This Clinical Practice Guideline document is based upon the best information available as of February 2011. It is designed to provide information and assist decision-making. It is not intended to define a standard of care, and should not be construed as one, nor should it be interpreted as prescribing an exclusive course of management. Variations in practice will inevitably and appropriately occur when clinicians take into account the needs of individual patients, available resources, and limitations unique to an institution or type of practice. Every health-care professional making use of these recommendations is responsible for evaluating the appropriateness of applying them in the setting of any particular clinical situation. The recommendations for research contained within this document are general and do not imply a specific protocol. SECTION II: DISCLOSURE Kidney Disease: Improving Global Outcomes (KDIGO) makes every effort to avoid any actual or reasonably perceived conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the Work Group. All members of the Work Group are required to complete, sign, and submit a disclosure and attestation form showing all such relationships that might be perceived or actual conflicts of interest. This document is updated annually and information is adjusted accordingly. All reported information is published in its entirety at the end of this document in the Work Group members' Biographical and Disclosure Information section, and is kept on file at the National Kidney Foundation (NKF), Managing Agent for KDIGO.
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            Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines.

            Fulvio Stacul, Aart J van der Molen, Peter Reimer … (2011)
            The Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) has updated its 1999 guidelines on contrast medium-induced nephropathy (CIN). Topics reviewed include the definition of CIN, the choice of contrast medium, the prophylactic measures used to reduce the incidence of CIN, and the management of patients receiving metformin. Key Points • Definition, risk factors and prevention of contrast medium induced nephropathy are reviewed. • CIN risk is lower with intravenous than intra-arterial iodinated contrast medium. • eGFR of 45 ml/min/1.73 m (2) is CIN risk threshold for intravenous contrast medium. • Hydration with either saline or sodium bicarbonate reduces CIN incidence. • Patients with eGFR ≥ 60 ml/min/1.73 m (2) receiving contrast medium can continue metformin normally.
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              Hypoxia of the renal medulla--its implications for disease.

              M Brezis, S. Rosén (1995)
              Article 0 comments Cited 189 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Emanuele Grassedonio: Role: ConceptualizationRole: Writing - review & editing
                Lorena Incorvaia: Role: ConceptualizationRole: Writing - review & editing
                Marco Guarneri: Role: ConceptualizationRole: Writing - review & editing
                Fabio Guagnini: Role: Writing - original draftRole: Writing - review & editing
                Massimo Midiri: Role: Writing - original draftRole: Writing - review & editing
                Journal
                Journal ID (nlm-ta): Drugs Context
                Journal ID (iso-abbrev): Drugs Context
                Journal ID (publisher-id): DIC
                Title: Drugs in Context
                Publisher: BioExcel Publishing Ltd
                ISSN (Print): 1745-1981
                ISSN (Electronic): 1740-4398
                Publication date Collection: 2024
                Publication date (Electronic): 14 March 2024
                Volume: 13
                Electronic Location Identifier: 2023-11-2
                Affiliations
                [1 ]Biomedicine Department, Neuroscience and Advance Diagnostics, University of Palermo, Palermo, Italy
                [2 ]Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), Section of Medical Oncology, University of Palermo, Palermo, Italy
                [3 ]Nephrology and Dialysis, Azienda Ospedaliera Universitaria “Paolo Giaccone” Polyclinic, Palermo, Italy
                [4 ]GE HealthCare Pharmaceutical Diagnostic (PDx), Milan, Italy
                Author notes
                Correspondence: Emanuele Grassedonio, Biomedicine Department, Neuroscience and Advance Diagnostics, University of Palermo, Palermo, Italy. Email: emanuele.grassedonio@ 123456unipa.it
                Article
                Publisher ID: dic-2023-11-2
                DOI: 10.7573/dic.2023-11-2
                PMC ID: 10954291
                PubMed ID: 38510312
                SO-VID: 05a30a67-ace7-4848-8e38-5dc713e6be75
                Copyright © Copyright © 2024 Grassedonio E, Incorvaia L, Guarneri M, Guagnini F, Midiri M
                License:

                Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0, which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

                History
                Date received : 08 November 2023
                Date accepted : 24 January 2024
                Funding
                Funded by: GE HealthCare, Pharmaceutical Diagnostics (PDx), Milan, Italy
                Categories
                Subject: Review

                Keywords: cancer,computed tomography,post-contrast acute kidney injury
                Data availability:
                Keywords: cancer, computed tomography, post-contrast acute kidney injury

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