Homeostatic changes of trace elements in diazinon toxicity in rat model: The beneficial role of resveratrol

Abstract

Background and objectives

Diazinon (DZN) is a cholinesterase inhibitor widely used to relieve agricultural pests and upgrade the productivity of crops. Resveratrol (Res), as a phenolic plant compound, has a protective role against free radicals. This study intended to evaluate the impacts of Res on homeostatic disturbances induced by DZN in rats.

Method

Twenty-four Wistar rats (4 weeks) were randomly distributed into four groups of six animals each. The first group (control group) received corn oil. The second group (Res group) received orally Res (20 mg/kg. The third group (DZN group) received the oral DZN (70 mg/kg); the fourth group (Res plus DZN group) was treated simultaneously with DZN (70 mg/kg) and Res (20 mg/kg); for a period of 5 weeks. The serum, liver, kidney, and heart levels of the Copper (Cu), zinc (Zn), iron (Fe), selenium (Se), and magnesium (Mg) as main trace elements are measured.

Results

DZN treatment decreased significantly serum, liver, kidney, and heart levels of Cu, Zn, Fe, Se, and Mg in comparison with the control group. Res administration enhanced serum, liver, kidney, and content of heart elements compared to the DZN group.

Conclusions

These results suggested that Res could ameliorate the homeostatic imbalance induced by DZN. Res had a protective effect against DZN-provoking heart, renal, and hepatic toxicity in animal models.

Graphical Abstract

Highlights

• •

  Diazinon (DZN) is a cholinesterase inhibitor used to relieve agricultural pests.

• •

  Resveratrol (Res) plant compound has a protective role against free radicals.

• •

  DZN treatment decreased significantly serum and tissue levels of Cu, Zn, Fe, Se, and Mg.

• •

  Res administration enhanced serum, liver, kidney, and content of heart elements.