Evaluation of the anti-inflammatory activities of tanshinones isolated from Salvia miltiorrhiza var. alba roots in THP-1 macrophages.

Lou, Hongxiang; Sun, Longru; Ji, Jianbo; Ma, Shuli; Zhang, Dawei

doi:10.1016/j.jep.2016.05.018

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Evaluation of the anti-inflammatory activities of tanshinones isolated from Salvia miltiorrhiza var. alba roots in THP-1 macrophages.

Author(s): Shuli Ma ¹ , Dawei Zhang ² , Hongxiang Lou ¹ , Longru Sun ³ , Jianbo Ji ¹

Publication date (Electronic): Jul 21 2016

Journal: Journal of ethnopharmacology

Publisher: Elsevier BV

Keywords: 1,2,6,7,8,9-hexahydro-1,6,6- trimethyl-3,11-dioxanaphtho [2,1-e] azulene-10,12-dione (PubChem CID: 14609845) , 2-isopropyl-8-methylphenanthrene-3,4-dione (PubChem CID: 135872), Anti-inflammatory activity, Atherosclerosis, Bioactivity evaluation, Pro-inflammatory cytokines, Tanshinones, arucadiol (PubChem CID: 11011966), danshenol A (PubChem CID: 3083514), sugiol (PubChem CID: 275529), tanshindiol C (PubChem CID: 5321620), tanshinone IIA (PubChem CID: 164676), tanshinone IIB (PubChem CID: 318797)

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Abstract

Salvia miltiorrhiza var. alba roots are used as the Chinese traditional medicine Danshen for the treatment of cardiovascular diseases in local clinical practice. Tanshinones are the major effective constituents of S. miltiorrhiza var. alba roots, but only tanshinone IIA, tanshinone I, cryptotanshinone, and 15,16-dihydrotanshinone have been investigated for their anti-inflammatory activities.

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Journal ID (iso-abbrev): J Ethnopharmacol

Title: Journal of ethnopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1872-7573

ISSN (Print): 0378-8741

Publication date (Electronic): Jul 21 2016

Volume: 188

Affiliations

[1 ] Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.

[2 ] Department of Vascular Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, PR China.

[3 ] Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China. Electronic address: sunlr@sdu.edu.cn.

Article

Publisher Item ID: S0378-8741(16)30281-1

DOI: 10.1016/j.jep.2016.05.018

PubMed ID: 27178632

SO-VID: 03d81948-854d-40cc-bab4-d60073cc3275

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Keywords: Atherosclerosis,Bioactivity evaluation,Pro-inflammatory cytokines,Tanshinones,arucadiol (PubChem CID: 11011966),danshenol A (PubChem CID: 3083514),sugiol (PubChem CID: 275529),tanshindiol C (PubChem CID: 5321620),tanshinone IIA (PubChem CID: 164676),tanshinone IIB (PubChem CID: 318797),1,2,6,7,8,9-hexahydro-1,6,6- trimethyl-3,11-dioxanaphtho [2,1-e] azulene-10,12-dione (PubChem CID: 14609845),2-isopropyl-8-methylphenanthrene-3,4-dione (PubChem CID: 135872),Anti-inflammatory activity

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Keywords: Atherosclerosis, Bioactivity evaluation, Pro-inflammatory cytokines, Tanshinones, arucadiol (PubChem CID: 11011966), danshenol A (PubChem CID: 3083514), sugiol (PubChem CID: 275529), tanshindiol C (PubChem CID: 5321620), tanshinone IIA (PubChem CID: 164676), tanshinone IIB (PubChem CID: 318797), 1,2,6,7,8,9-hexahydro-1,6,6- trimethyl-3,11-dioxanaphtho [2,1-e] azulene-10,12-dione (PubChem CID: 14609845), 2-isopropyl-8-methylphenanthrene-3,4-dione (PubChem CID: 135872), Anti-inflammatory activity

Evaluation of the anti-inflammatory activities of tanshinones isolated from Salvia miltiorrhiza var. alba roots in THP-1 macrophages.

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