Trends in disease burden due to nonalcoholic fatty liver disease in Jiangsu Province from 1990 to 2019

Abstract

Objective To investigate the trends in disease burden due to nonalcoholic fatty liver disease (NAFLD) in Jiangsu Province, so as to provide insights into the formulation of the NAFLD control strategy.

Methods The prevalence, mortality, disability-adjusted life year (DALY), standardized prevalence, standardized mortality and standardized DALY rate of NALFD in Jiangsu Province from 1990 to 2019 were captured from the Global Burden of Disease Study 2019 (GBD2019) dataset, and the trends in disease burden due to NALFD were evaluated with annual percent change (APC) using the software Joinpoint 4.2.

Results The prevalence, mortality, DALY rate of NAFLD were 22.52%, 1.35/10 ⁵ and 31.36/10 ⁵, which all appeared a rise with age, and the standardized prevalence, mortality, DALY rate of NAFLD were 16.04%, 0.84/10 ⁵ and 19.73/10 ⁵ in Jiangsu Province in 2019. The prevalence of NAFLD appeared an overall tendency towards a rise in Jiangsu Province from 1990 to 2019 (APC = 2.2%, t = 7.8, P<0.01), and the mortality appeared an overall tendency towards a decline (APC = −2.2%, t = −3.6, P <0.01), while the DALY rate appeared an overall tendency towards a decline, with a 43.12% reduction over the 30 years (APC = −2.8%, t = −4.3, P<0.01).

Conclusions The prevalence of NAFLD appeared a tendency towards a rise in Jiangsu Province from 1990 to 2019, and the disease burden due to NAFLD increased with age. Early identification, early diagnosis and early treatment may improve the prognosis of NAFLD and patients’ quality of life.

Abstract

摘要：目的 掌握江苏省非酒精性脂肪肝 (nonalcoholic fatty liver disease, NAFLD) 疾病负担变化趋势, 为制定防治策略提 供依据。 方法 摘取 2019 年全球疾病负担数据 (Global Burden of Disease Study 2019, GBD2019) 中江苏省1990—2019年 NAFLD的患病率、死亡率、伤残调整生命年(DALY)率及标化率, 采用Joinpoint 4.2软件计算年度变化百分比(APC) 。 结果 2019 年江苏省NAFLD患病率、死亡率、DALY率分别为 22.52%、1.35/10万、31.36/10万, 标化率分别为 16.04%、 0.84/10万、19.73/10万, 均随着年龄的增长而增长。1990—2019 年江苏省NAFLD患病率总体呈上升趋势, 30 年上升了 87.33% (APC = 2.2%, t = 7.8, P<0.01); 死亡率总体呈下降趋势, 30 年下降了 33.00% (APC = −2.2%, t = −3.6, P<0.01); DALY 率总体呈下降趋势, 30 年下降了 43.12% (APC = −2.8%, t = −4.3, P<0.01)。 结论 1990—2019 年江苏省NAFLD患病率呈上 升趋势, 随着年龄的增加疾病负担增加。