Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population.

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Abstract

Biomarkers to improve the risk-benefit of extended adjuvant endocrine therapy for late recurrence in patients with oestrogen-receptor-positive breast cancer would be clinically valuable. We compared the prognostic ability of the breast-cancer index (BCI) assay, 21-gene recurrence score (Oncotype DX), and an immunohistochemical prognostic model (IHC4) for both early and late recurrence in patients with oestrogen-receptor-positive, node-negative (N0) disease who took part in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) clinical trial.

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Journal

Journal ID (iso-abbrev): Lancet Oncol

Title: The Lancet. Oncology

Publisher: Elsevier BV

ISSN (Electronic): 1474-5488

ISSN (Print): 1470-2045

Publication date (Electronic): Oct 2013

Volume: 14

Issue: 11

Affiliations

[1 ] Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Boston, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Charlestown, Boston, MA, USA. Electronic address: dsgroi@partners.org.

[2 ] Centre for Cancer Prevention, Queen Mary University, London, UK.

[3 ] bioTheranostics, San Diego, CA, USA.

[4 ] Breakthrough Breast Cancer Centre, Royal Marsden Hospital, London, UK; Department of Biochemistry, University of Otago, Dunedin, New Zealand.

[5 ] Breakthrough Breast Cancer Centre, Royal Marsden Hospital, London, UK.

[6 ] Center for Cancer Research, Massachusetts General Hospital, Charlestown, Boston, MA, USA.

[7 ] Breakthrough Breast Cancer Centre, Royal Marsden Hospital, London, UK; Institute of Cancer Research and Academic Department of Biochemistry, Royal Marsden Hospital, London, UK.

Article

Mid ID: NIHMS540421 Publisher Item ID: S1470-2045(13)70387-5

DOI: 10.1016/S1470-2045(13)70387-5

PMC ID: 3918681

PubMed ID: 24035531

SO-VID: 02e60e22-daa0-40e5-a9c9-aaf61942d3a6

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