This work examines the opportunities and obstacles related to the novel idea of transforming nuclear waste into biodiesel in the Indian setting. Given India’s increasing energy needs and the necessity for sustainable options, repurposing nuclear waste for biodiesel production presents a unique strategy. The paper examines the possible advantages of this approach, covering economic, environmental, and technological factors, as well as discussing the associated difficulties, such as safety issues, technical obstacles, and public perception intricacies. The goal is to provide valuable information for future research and development endeavors by examining India’s distinct nuclear waste and biodiesel environment, considering socio-economic aspects, legislative structures, and the changing energy industry. The paper provides a detailed analysis that adds to the ongoing discussion on sustainable energy choices, emphasizing the significance of creative strategies in addressing energy demands and handling nuclear waste efficiently.