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      • Record: found
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      Tenascin-C Levels in the Vitreous of Patients with Proliferative Vitreoretinopathy

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          Abstract

          Purpose: To determine whether tenascin-C levels are elevated in the vitreous of patients with proliferative vitreoretinopathy (PVR). Methods: We assayed tenascin-C levels in vitreous samples of 110 consecutive patients with PVR (30 eyes), rhegmatogenous retinal detachment (RRD; 32 eyes), and macular hole or idiopathic epiretinal membrane (controls, 48 eyes) using an enzyme-linked immunosorbent assay. Results: Vitreous levels of tenascin-C (median [range]) were significantly greater in PVR (845.0 ng/ml [411.0–1,050.0]) than in RRD (21.9 ng/ml [13.2–127.0]) and in the controls (18.0 ng/ml [9.9–199.0]) (p < 0.0001). Conclusion: The results indicate the possibility that tenascin-C is involved in the pathogenesis of PVR.

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          Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis.

          R Chiquet-Ehrismann, Heidi Pearson, E. Blanchette … (1986)
          The extracellular matrix protein tenascin (previously described as myotendinous antigen) is selectively present in the mesenchyme surrounding fetal rat mammary glands, hair follicles, and teeth, three organ anlagen where the mesenchyme is essential for development. No tenascin is detectable in the normal adult mammary gland. Carcinogen-induced mammary tumors contained tenascin in their fibrous tissue. As reported for the molecule described as a "hexabrachion," tenascin contaminates so-called "cell-surface fibronectin," where it accounts for most of the detectable hemagglutinating activity. Of the extracellular matrix proteins compared, tenascin is the least effective substrate for attachment of primary mammary tumor cells, but the most effective in promoting cell growth after serum is removed from the culture medium.
          Article 0 comments Cited 93 times – based on 0 reviews     Review now
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            Author and article information

            Journal
            Journal ID (publisher-id): OPH
            Journal ID (nlm-ta): Ophthalmologica
            Journal ID (doi): 10.1159/issn.0030-3755
            Title: Ophthalmologica
            Publisher: S. Karger AG
            ISSN (Print): 0030-3755
            ISSN (Electronic): 1423-0267
            Publication date Subscription-year: 2003
            Publication date (Print): December 2003
            Publication date (Electronic): 30 October 2003
            Volume: 217
            Issue: 6
            Pages: 422-425
            Affiliations
            aDepartment of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo; bDepartment of Ophthalmology, Toho University Sakura Hospital, Sakura, Chiba; cDepartment of Ophthalmology, Hokkaido University School of Medicine, Sapporo; dExperimental Animal Division, Bio Resource Center, Riken, Tsukuba, and eANB Tsukuba Institute, Aloka, Ibaraki, Japan
            Article
            Publisher ID: 73073 Other ID: Ophthalmologica 2003;217:422–425
            DOI: 10.1159/000073073
            PubMed ID: 14573976
            SO-VID: 023c5baf-b9c6-4455-94b0-b1594913ca1c
            Copyright © © 2003 S. Karger AG, Basel
            License:

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Date received : 23 April 2003
            Date accepted : 30 December 2003
            Page count
            Figures: 2, References: 12, Pages: 4
            Categories
            Subject: Original Paper

            ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
            Keywords: Tenascin-C,Proliferative vitreoretinopathy,Enzyme-linked immunosorbent assay,Vitreous
            Data availability:
            ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
            Keywords: Tenascin-C, Proliferative vitreoretinopathy, Enzyme-linked immunosorbent assay, Vitreous

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