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      A global quantification of “normal” sleep schedules using smartphone data

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          Abstract

          Using data collected through smartphones, we assess the effects of age, sex, lighting, and home country on sleep.

          Abstract

          The influence of the circadian clock on sleep scheduling has been studied extensively in the laboratory; however, the effects of society on sleep remain largely unquantified. We show how a smartphone app that we have developed, ENTRAIN, accurately collects data on sleep habits around the world. Through mathematical modeling and statistics, we find that social pressures weaken and/or conceal biological drives in the evening, leading individuals to delay their bedtime and shorten their sleep. A country’s average bedtime, but not average wake time, predicts sleep duration. We further show that mathematical models based on controlled laboratory experiments predict qualitative trends in sunrise, sunset, and light level; however, these effects are attenuated in the real world around bedtime. Additionally, we find that women schedule more sleep than men and that users reporting that they are typically exposed to outdoor light go to sleep earlier and sleep more than those reporting indoor light. Finally, we find that age is the primary determinant of sleep timing, and that age plays an important role in the variability of population-level sleep habits. This work better defines and personalizes “normal” sleep, produces hypotheses for future testing in the laboratory, and suggests important ways to counteract the global sleep crisis.

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          Most cited references9

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          Life between clocks: daily temporal patterns of human chronotypes.

          Human behavior shows large interindividual variation in temporal organization. Extreme "larks" wake up when extreme "owls" fall asleep. These chronotypes are attributed to differences in the circadian clock, and in animals, the genetic basis of similar phenotypic differences is well established. To better understand the genetic basis of temporal organization in humans, the authors developed a questionnaire to document individual sleep times, self-reported light exposure, and self-assessed chronotype, considering work and free days separately. This report summarizes the results of 500 questionnaires completed in a pilot study individual sleep times show large differences between work and free days, except for extreme early types. During the workweek, late chronotypes accumulate considerable sleep debt, for which they compensate on free days by lengthening their sleep by several hours. For all chronotypes, the amount of time spent outdoors in broad daylight significantly affects the timing of sleep: Increased self-reported light exposure advances sleep. The timing of self-selected sleep is multifactorial, including genetic disposition, sleep debt accumulated on workdays, and light exposure. Thus, accurate assessment of genetic chronotypes has to incorporate all of these parameters. The dependence of human chronotype on light, that is, on the amplitude of the light:dark signal, follows the known characteristics of circadian systems in all other experimental organisms. Our results predict that the timing of sleep has changed during industrialization and that a majority of humans are sleep deprived during the workweek. The implications are far ranging concerning learning, memory, vigilance, performance, and quality of life.
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            Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.

            1. The circadian timing system has been implicated in age-related changes in sleep structure, timing and consolidation in humans. 2. We investigated the circadian regulation of sleep in 13 older men and women and 11 young men by forced desynchrony of polysomnographically recorded sleep episodes (total, 482; 9 h 20 min each) and the circadian rhythms of plasma melatonin and core body temperature. 3. Stage 4 sleep was reduced in older people. Overall levels of rapid eye movement (REM) sleep were not significantly affected by age. The latencies to REM sleep were shorter in older people when sleep coincided with the melatonin rhythm. REM sleep was increased in the first quarter of the sleep episode and the increase of REM sleep in the course of sleep was diminished in older people. 4. Sleep propensity co-varied with the circadian rhythms of body temperature and plasma melatonin in both age groups. Sleep latencies were longest just before the onset of melatonin secretion and short sleep latencies were observed close to the temperature nadir. In older people sleep latencies were longer close to the crest of the melatonin rhythm. 5. In older people sleep duration was reduced at all circadian phases and sleep consolidation deteriorated more rapidly during the course of sleep, especially when the second half of the sleep episode occurred after the crest of the melatonin rhythm. 6. The data demonstrate age-related decrements in sleep consolidation and increased susceptibility to circadian phase misalignment in older people. These changes, and the associated internal phase advance of the propensity to awaken from sleep, appear to be related to the interaction between a reduction in the homeostatic drive for sleep and a reduced strength of the circadian signal promoting sleep in the early morning.
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              Sex difference in sleep-time preference and sleep need: a cross-sectional survey among Italian pre-adolescents, adolescents, and adults.

              The aim of this study was to examine sex differences in sleep-time preference by age among Italian pre-adolescents, adolescents, and adults. The final sample consisted of 8,972 participants (5,367 females and 3,605 males) from 10 to 87 yrs of age. To assess preferred sleep habits, we considered the answers to the open-ended questions of the Morningness-Eveningness Questionnaire (MEQ). In agreement with previous studies, we found that sleep-time preference started to shift toward eveningness from the age of 13 yrs. Females reached their peak in eveningness earlier (about 17 yrs of age) than males (about 21 yrs of age). Thereafter, the ideal sleep-time preference advanced in men and women with increasing age. Females presented a more significant advanced sleep phase than males only during the years when sexual hormones are typically active. Moreover, females reported a longer ideal sleep duration than males across all age groups examined, except in over 55 yrs one.
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                Author and article information

                Journal
                Sci Adv
                Sci Adv
                SciAdv
                advances
                Science Advances
                American Association for the Advancement of Science
                2375-2548
                May 2016
                06 May 2016
                : 2
                : 5
                : e1501705
                Affiliations
                [1 ]Department of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA.
                [2 ]Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
                Author notes
                [* ]Corresponding author. Email: forger@ 123456umich.edu
                Article
                1501705
                10.1126/sciadv.1501705
                4928979
                27386531
                018039c8-54e2-4029-83de-3660d8a035eb
                Copyright © 2016, The Authors

                This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

                History
                : 24 November 2015
                : 23 February 2016
                Funding
                Funded by: U.S. Army Research Laboratory (US);
                Award ID: ID0EWJBG5657
                Award ID: W911NF-13-1-0449
                Award Recipient :
                Funded by: Human Frontier Science Program (FR);
                Award ID: ID0EWRBG5658
                Award ID: RPG 24/2012
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/100000181, Air Force Office of Scientific Research;
                Award ID: ID0EWZBG5659
                Award ID: FA 9550-14-1-0092
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/100000086, Directorate for Mathematical and Physical Sciences;
                Award ID: ID0EZBAI5660
                Award ID: DGE 1256260
                Award Recipient :
                Categories
                Research Article
                Research Articles
                SciAdv r-articles
                Sleep Research
                Custom metadata
                Judith Urtula

                smart phones,sleep,sleep schedules
                smart phones, sleep, sleep schedules

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