The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma.

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Abstract

We recently reported that 95% of chondroblastomas harbour a p.K36M mutation in either H3F3A (chromosome 1) or H3F3B (chromosome 17), with the majority involving H3F3B. The aim of this study was to assess the expression of the K36M-mutated protein by immunohistochemistry in a large group of tumours.

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Author and article information

Journal

Journal ID (iso-abbrev): Histopathology

Title: Histopathology

Publisher: Wiley-Blackwell

ISSN (Electronic): 1365-2559

ISSN (Print): 0309-0167

Publication date (Electronic): Jul 2016

Volume: 69

Issue: 1

Affiliations

[1 ] Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK.

[2 ] UCL Cancer Institute, Huntley Street, London, UK.

[3 ] Department of Anatomical Pathology, A. C. Camargo Cancer Centre, Sao Paulo, Brazil.

[4 ] Department of Radiology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK.

[5 ] Bone Tumour Reference Centre at the Institute of Pathology, University Hospital Basel, Basel, Switzerland.

Article

DOI: 10.1111/his.12945

PubMed ID: 26844533

SO-VID: 016c1220-d003-4666-8c22-d59f905f91b9

History

Keywords: H3F3A,H3F3B,K36M,bone tumour,chondroblastoma

Data availability:

Keywords: H3F3A, H3F3B, K36M, bone tumour, chondroblastoma

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