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      Regional differences in the care and outcomes of acute stroke patients in Australia: an observational study using evidence from the Australian Stroke Clinical Registry (AuSCR)

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          Abstract

          Objective

          To compare the processes and outcomes of care in patients who had a stroke treated in urban versus rural hospitals in Australia.

          Design

          Observational study using data from a multicentre national registry.

          Setting

          Data from 50 acute care hospitals in Australia (25 urban, 25 rural) which participated in the Australian Stroke Clinical Registry during the period 2010–2015.

          Participants

          Patients were divided into two groups (urban, rural) according to the Australian Standard Geographical Classification Remoteness Area classification. Data pertaining to 28 115 patients who had a stroke were analysed, of whom 8159 (29%) were admitted to hospitals located within rural areas.

          Primary and secondary outcome measures

          Regional differences in processes of care (admission to a stroke unit, thrombolysis for ischaemic stroke, discharge on antihypertensive medication and provision of a care plan), and survival analyses up to 180 days and health-related quality of life at 90–180 days.

          Results

          Compared with those admitted to urban hospitals, patients in rural hospitals less often received thrombolysis (urban 12.7% vs rural 7.5%, p<0.001) or received treatment in stroke units (urban 82.2% vs rural 76.5%, p<0.001), and fewer were discharged with a care plan (urban 61.3% vs rural 44.7%, p<0.001). No significant differences were found in terms of survival or overall self-reported quality of life.

          Conclusions

          Rural access to recommended components of acute stroke care was comparatively poorer; however, this did not appear to impact health outcomes at approximately 6 months.

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          Most cited references38

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          EuroQol - a new facility for the measurement of health-related quality of life

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            The Design and Administration of Mail Surveys

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              Organised inpatient (stroke unit) care for stroke.

              (2013)
              Organised stroke unit care is provided by multidisciplinary teams that exclusively manage stroke patients in a ward dedicated to stroke patients, with a mobile stroke team or within a generic disability service (mixed rehabilitation ward). To assess the effect of stroke unit care compared with alternative forms of care for people following a stroke. We searched the trials registers of the Cochrane Stroke Group (January 2013) and the Cochrane Effective Practice and Organisation of Care (EPOC) Group (January 2013), MEDLINE (2008 to September 2012), EMBASE (2008 to September 2012) and CINAHL (1982 to September 2012). In an effort to identify further published, unpublished and ongoing trials, we searched 17 trial registers (January 2013), performed citation tracking of included studies, checked reference lists of relevant articles and contacted trialists. Randomised controlled clinical trials comparing organised inpatient stroke unit care with an alternative service. After formal risk of bias assessment, we have now excluded previously included quasi-randomised trials. Two review authors initially assessed eligibility and trial quality. We checked descriptive details and trial data with the co-ordinators of the original trials. We included 28 trials, involving 5855 participants, comparing stroke unit care with an alternative service. More-organised care was consistently associated with improved outcomes. Twenty-one trials (3994 participants) compared stroke unit care with care provided in general wards. Stroke unit care showed reductions in the odds of death recorded at final (median one year) follow-up (odds ratio (OR) 0.87, 95% confidence interval (CI) 0.69 to 0.94; P = 0.005), the odds of death or institutionalised care (OR 0.78, 95% CI 0.68 to 0.89; P = 0.0003) and the odds of death or dependency (OR 0.79, 95% CI 0.68 to 0.90; P = 0.0007). Sensitivity analyses indicated that the observed benefits remained when the analysis was restricted to securely randomised trials that used unequivocally blinded outcome assessment with a fixed period of follow-up. Outcomes were independent of patient age, sex, initial stroke severity or stroke type, and appeared to be better in stroke units based in a discrete ward. There was no indication that organised stroke unit care resulted in a longer hospital stay. Stroke patients who receive organised inpatient care in a stroke unit are more likely to be alive, independent, and living at home one year after the stroke. The benefits were most apparent in units based in a discrete ward. We observed no systematic increase in the length of inpatient stay.
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                Author and article information

                Journal
                BMJ Open
                BMJ Open
                bmjopen
                bmjopen
                BMJ Open
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                2044-6055
                2021
                1 April 2021
                : 11
                : 4
                : e040418
                Affiliations
                [1 ] departmentTasmanian School of Medicine, College of Health and Medicine , University of Tasmania , Hobart, Tasmania, Australia
                [2 ] departmentSchool of Nursing, College of Health and Medicine , University of Tasmania , Launceston, Tasmania, Australia
                [3 ] departmentSchool of Pharmacy and Pharmacology, College of Health and Medicine , University of Tasmania , Hobart, Tasmania, Australia
                [4 ] departmentCentre of Education and Research Nursing and Midwifery , Royal Hobart Hospital , Hobart, Tasmania, Australia
                [5 ] departmentMenzies Institute for Medical Research , University of Tasmania , Hobart, Tasmania, Australia
                [6 ] departmentDepartment of Public Health Management , Pham Ngoc Thach University of Medicine , Ho Chi Minh City, Viet Nam
                [7 ] departmentNeurology Department , Royal Hobart Hospital , Hobart, Tasmania, Australia
                [8 ] departmentPrincess Alexandra Hospital , QLD Health , Woolloongabba, Queensland, Australia
                [9 ] departmentTownsville Hospital , QLD Health , Townsville, Queensland, Australia
                [10 ] departmentOrange and Bathurst Health Services , NSW Health , North Sydney, New South Wales, Australia
                [11 ] departmentInpatient Rehabilitation , Echuca Regional Health , Echuca, Victoria, Australia
                [12 ] departmentStroke and Ageing Research, Department of Medicine, School of Clinical Sciences , Monash University , Clayton, Victoria, Australia
                [13 ] departmentFlorey Institute of Neuroscience and Mental Health , University of Melbourne , Melbourne, Victoria, Australia
                [14 ] departmentDepartment of Neuroscience, Central Clinical School , Monash University , Melbourne, Victoria, Australia
                [15 ] departmentOccupational Therapy Department , Alfred Hospital , Melbourne, Victoria, Australia
                Author notes
                [Correspondence to ] Dr Natasha A Lannin; Natasha.Lannin@ 123456monash.edu

                DAC and NAL are joint senior authors.

                Author information
                http://orcid.org/0000-0002-9956-2569
                http://orcid.org/0000-0002-6764-3882
                http://orcid.org/0000-0003-0506-2924
                http://orcid.org/0000-0001-8162-682X
                http://orcid.org/0000-0002-2066-8345
                Article
                bmjopen-2020-040418
                10.1136/bmjopen-2020-040418
                8021749
                33795291
                00fa3beb-7b60-453a-a3e7-fef6ecc2abfe
                © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

                This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:  http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 13 May 2020
                : 30 November 2020
                : 07 December 2020
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100000930, National Stroke Foundation;
                Award ID: Not applicable
                Funded by: http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
                Award ID: 1034415
                Funded by: FundRef http://dx.doi.org/10.13039/100007819, Allergan;
                Award ID: Not applicable
                Funded by: FundRef http://dx.doi.org/10.13039/501100001779, Monash University;
                Award ID: Not applicable
                Funded by: FundRef http://dx.doi.org/10.13039/100013733, Ipsen Biopharmaceuticals;
                Award ID: Not applicable
                Funded by: FundRef http://dx.doi.org/10.13039/100001003, Boehringer Ingelheim;
                Award ID: Not applicable
                Funded by: FundRef http://dx.doi.org/10.13039/100010230, Department of Health, Queensland;
                Award ID: Not applicable
                Funded by: Heart Foundation;
                Award ID: 102055
                Categories
                Cardiovascular Medicine
                1506
                1683
                Original research
                Custom metadata
                unlocked

                Medicine
                stroke medicine,organisation of health services,accident & emergency medicine,quality in health care

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