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      Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation

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          Abstract

          The study combined UHPLC-Q-Orbitrap-MS analysis with authentic standards, to create a novel strategy for isomers recognition and putative identification. Through the strategy, anti-Covid-19 Jinhua Qinggan Granule was found to comprise 28 isomers and 45 potential anti-Covid-19 constituents. The detection of three constituents (Danshensu, cryptotanshin, and tanshinone IIA) suggests Danshen as confidential additive. Based on this, 6 constituents are recommended as quality-marker candidates, including chlorogenic acid, acteoside, peimisine, baicalein, licoricesaponin H2, and tanshinone IIA. Obviously, the study can not only help the public to really understand the Granule’s formula and chemistry, but also facilitate its Pharmacopoeia collection in future.

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          Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review

          In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Glycyrrhiza glabra Linn. belongs to the Fabaceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as glycyrrhizin, 18β‐glycyrrhetinic acid, glabrin A and B, and isoflavones, that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antibacterial, anti‐inflammatory, antiviral, antioxidant, and antidiabetic activities. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for G. glabra . Therefore, an updated, critical, and extensive overview on the current knowledge of G. glabra composition and biological activities is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well‐being.
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            Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine

            Graphical abstract Lonicera japonica has been used for thousands of years in China. Now, more than 140 chemical compounds have been isolated; and studies show Lonicera japonica possesses wide pharmacological actions. Meanwhile, it could be used as healthy food, ornamental groundcover, etc.
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              Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

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                Author and article information

                Contributors
                Role: Formal analysisRole: MethodologyRole: Visualization
                Role: ConceptualizationRole: Visualization
                Role: SoftwareRole: Data curationRole: Visualization
                Role: SoftwareRole: Data curationRole: Visualization
                Role: Writing – review & editingRole: Visualization
                Journal
                J Food Drug Anal
                J Food Drug Anal
                Journal of Food and Drug Analysis
                Taiwan Food and Drug Administration
                1021-9498
                2224-6614
                2023
                31 August 2023
                : 31
                : 3
                : 534-551
                Affiliations
                [a ]School of Chinese Herbal Medicines, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of China
                [b ]College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China
                Author notes
                [* ]Corresponding author. E-mail address: lixican@ 123456126.com (X. Li).
                Article
                jfda-31-03-534
                10.38212/2224-6614.3466
                10629912
                00b77de0-5a31-486f-a56f-a87e2a3642e3
                © 2023 Taiwan Food and Drug Administration

                This is an open access article under the CC-BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 18 February 2023
                : 22 May 2023
                Categories
                Original Article

                isomer recognition,pharmacopoeia collection,q-marker,quality-control,three chinese medicines and three chinese recipes

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